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Early life adversit...
Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties
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- Treccani, Giulia (författare)
- Universitätsmedizin Mainz
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- Yigit, Hatice (författare)
- Johannes-Gutenberg University Mainz
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- Lingner, Thomas (författare)
- Genevention GmbH
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- Schleuβner, Vanessa (författare)
- Johannes-Gutenberg University Mainz,Universitätsmedizin Mainz
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- Mey, Franziska (författare)
- Universitätsmedizin Mainz
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- van der Kooij, Michael A. (författare)
- Universitätsmedizin Mainz
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- Wennström, Malin (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Herzog, David P. (författare)
- Universitätsmedizin Mainz
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- Linke, Matthias (författare)
- Universitätsmedizin Mainz
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- Fricke, Markus (författare)
- Genevention GmbH
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- Schmeisser, Michael J. (författare)
- Universitätsmedizin Mainz
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- Wegener, Gregers (författare)
- Aarhus University
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- Mittmann, Thomas (författare)
- Universitätsmedizin Mainz
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- Trotter, Jacqueline (författare)
- Universitätsmedizin Mainz,Johannes-Gutenberg University Mainz
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- Müller, Marianne B. (författare)
- Universitätsmedizin Mainz
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: Neurobiology of Stress. - : Elsevier BV. - 2352-2895. ; 15
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The precise mechanisms underlying the detrimental effects of early life adversity (ELA) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of stress-related brain function. Here, we have investigated the impact of ELA, in the form of a limited bedding and nesting material (LBN) paradigm, on a glial subpopulation with unique properties in brain homeostasis, the NG2+ cells. First, we have established a link between maternal behavior, activation of the offspring's stress response and heterogeneity in the outcome to LBN manipulation. We further showed that LBN targets the hippocampal NG2+ transcriptome with glucocorticoids being an important mediator of the LBN-induced molecular changes. LBN altered the NG2+ transcriptome and these transcriptional effects were correlated with glucocorticoids levels. The functional relevance of one LBN-induced candidate gene, Scn7a, could be confirmed by an increase in the density of voltage-gated sodium (Nav) channel activated currents in hippocampal NG2+ cells. Scn7a remained upregulated until adulthood in LBN animals, which displayed impaired cognitive performance. Considering that Nav channels are important for NG2+ cell-to-neuron communication, our findings provide novel insights into the disruption of this process in LBN mice.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Early life stress
- Na-channels
- NG2+ glia
- Scn7a
- Transcriptome
- Translational psychiatry
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Treccani, Giulia
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Yigit, Hatice
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Lingner, Thomas
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Schleuβner, Vane ...
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Mey, Franziska
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van der Kooij, M ...
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visa fler...
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Wennström, Malin
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Herzog, David P.
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Linke, Matthias
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Fricke, Markus
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Schmeisser, Mich ...
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Wegener, Gregers
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Mittmann, Thomas
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Trotter, Jacquel ...
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Müller, Marianne ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Neurobiology of ...
- Av lärosätet
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Lunds universitet