Sökning: onr:"swepub:oai:lup.lub.lu.se:c425b721-e539-4e88-8475-dd9c4af51632" > Enhanced predictive...
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000 | 04082naa a2200397 4500 | |
001 | oai:lup.lub.lu.se:c425b721-e539-4e88-8475-dd9c4af51632 | |
003 | SwePub | |
008 | 180122s2018 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/c425b721-e539-4e88-8475-dd9c4af516322 URI |
024 | 7 | a https://doi.org/10.2337/dc17-13512 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Pareek, Mananu Odense University Hospital,Brigham and Women's Hospital / Harvard Medical School4 aut |
245 | 1 0 | a Enhanced predictive capability of a 1-hour oral glucose tolerance test : A prospective population-based cohort study |
264 | c 2017-11-14 | |
264 | 1 | b American Diabetes Association,c 2018 |
300 | a 7 s. | |
520 | a OBJECTIVE To examine whether the 1-h blood glucose measurement would be a more suitable screening tool for assessing the risk of diabetes and its complications than the 2-h measurement. RESEARCH DESIGN AND METHODS We conducted a prospective population-based cohort study of 4,867men, randomly selected fromprespecified birth cohorts between 1921 and 1949,who underwent an oral glucose tolerance test with blood glucose measurements at 0, 1, and 2 h. Subjects were followed for up to 39 years, with registry-based recording of events. Discriminative abilities of elevated 1-h (≥8.6 mmol/L) versus 2-h (≥7.8 mmol/L) glucose for predicting incident type 2 diabetes, vascular complications, andmortality were compared using Kaplan-Meier analysis, Cox proportional hazards regression, and net reclassification improvement. RESULTS Median agewas 48 years (interquartile range [IQR] 48-49). During follow-up (median 33 years [IQR 24-37]), 636 (13%) developed type 2 diabetes. Elevated 1-h glucose was associatedwith incident diabetes (hazard ratio 3.40 [95% CI 2.90-3.98], P < 0.001) and provided better risk assessment than impaired glucose tolerance (Harrell concordance index 0.637 vs. 0.511, P < 0.001). Addition of a 1-hmeasurement in subjects stratified by fasting glucose provided greater net reclassification improvement than the addition of a 2-h measurement (0.214 vs. 0.016, respectively). Finally, the 1-h glucose was significantly associated with vascular complications and mortality. CONCLUSIONS The 1-h blood glucose level is a stronger predictor of future type 2 diabetes than the 2-h level and is associated with diabetes complications and mortality. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Bhatt, Deepak L.u Brigham and Women's Hospital / Harvard Medical School4 aut |
700 | 1 | a Nielsen, Mette L.u Odense University Hospital4 aut |
700 | 1 | a Jagannathan, Ramu New York University4 aut |
700 | 1 | a Eriksson, Karl Fredriku Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-ker |
700 | 1 | a Nilsson, Peter M.u Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medf-pni |
700 | 1 | a Bergman, Michaelu New York University4 aut |
700 | 1 | a Olsen, Michael H.u Odense University Hospital4 aut |
710 | 2 | a Odense University Hospitalb Brigham and Women's Hospital / Harvard Medical School4 org |
773 | 0 | t Diabetes Cared : American Diabetes Associationg 41:1, s. 171-177q 41:1<171-177x 0149-5992x 1935-5548 |
856 | 4 | u http://dx.doi.org/10.2337/dc17-1351y FULLTEXT |
856 | 4 | u https://care.diabetesjournals.org/content/diacare/41/1/171.full.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/c425b721-e539-4e88-8475-dd9c4af51632 |
856 | 4 8 | u https://doi.org/10.2337/dc17-1351 |
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