Sökning: onr:"swepub:oai:lup.lub.lu.se:c49a8091-b496-4caf-b6bf-b3d6ac0dae79" >
Polygenic scores, d...
Polygenic scores, diet quality, and type 2 diabetes risk : An observational study among 35,759 adults from 3 US cohorts
-
- Merino, Jordi (författare)
- Broad Institute,Massachusetts General Hospital,Harvard Medical School
-
- Guasch-Ferré, Marta (författare)
- Harvard Medical School,Harvard University
-
- Li, Jun (författare)
- Harvard University
-
visa fler...
-
- Chung, Wonil (författare)
- Harvard University,Dalian Maritime University
-
- Hu, Yang (författare)
- Harvard University
-
- Ma, Baoshan (författare)
- Dalian Maritime University,Harvard University
-
- Li, Yanping (författare)
- Harvard University
-
- Kang, Jae H. (författare)
- Harvard Medical School
-
- Kraft, Peter (författare)
- Harvard University
-
- Liang, Liming (författare)
- Harvard University
-
- Sun, Qi (författare)
- Harvard University,Harvard Medical School
-
- Franks, Paul W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University
-
- Manson, Jo Ann E. (författare)
- Harvard Medical School,Harvard University
-
- Willet, Walter C. (författare)
- Harvard University,Harvard Medical School
-
- Florez, Jose C. (författare)
- Broad Institute,Massachusetts General Hospital,Harvard Medical School
-
- Hu, Frank B. (författare)
- Harvard University,Harvard Medical School
-
visa färre...
-
(creator_code:org_t)
- 2022-04-26
- 2022
- Engelska.
-
Ingår i: PLoS Medicine. - : Public Library of Science (PLoS). - 1549-1277 .- 1549-1676. ; 19:4
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background Bothgenetic and lifestyle factors contribute to the risk of type 2 diabetes, but the extent to which there is a synergistic effect of the 2 factors is unclear. The aim of this study was to examine the joint associations of genetic risk and diet quality with incident type 2 diabetes. Methods and findings We analyzed data from 35,759 men and women in the United States participating in the Nurses’ Health Study (NHS) I (1986 to 2016) and II (1991 to 2017) and the Health Professionals Follow-up Study (HPFS; 1986 to 2016) with available genetic data and who did not have diabetes, cardiovascular disease, or cancer at baseline. Genetic risk was characterized using both a global polygenic score capturing overall genetic risk and pathway-specific polygenic scores denoting distinct pathophysiological mechanisms. Diet quality was assessed using the Alternate Healthy Eating Index (AHEI). Cox models were used to calculate hazard ratios (HRs) for type 2 diabetes after adjusting for potential confounders. WAU ith: Pleas over 902,386 person-years of follow-up, 4,433 participants were diagnosed with type 2 diabetes. The relative risk of type 2 diabetes was 1.29 (95% confidence interval [CI] 1.25, 1.32; P < 0.001) per standard deviation (SD) increase in global polygenic score and 1.13 (1.09, 1.17; P < 0.001) per 10-unit decrease in AHEI. Irrespective of genetic risk, low diet quality, as compared to high diet quality, was associated with approximately 30% increased risk of type 2 diabetes (Pinteraction = 0.69). The joint association of low diet quality and increased genetic risk was similar to the sum of the risk associated with each factor alone (Pinteraction = 0.30). Limitations of this study include the self-report of diet information and possible bias resulting from inclusion of highly educated participants with available genetic data. Conclusions These data provide evidence for the independent associations of genetic risk and diet quality with incident type 2 diabetes and suggest that a healthy diet is associated with lower diabetes risk across all levels of genetic risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Merino, Jordi
-
Guasch-Ferré, Ma ...
-
Li, Jun
-
Chung, Wonil
-
Hu, Yang
-
Ma, Baoshan
-
visa fler...
-
Li, Yanping
-
Kang, Jae H.
-
Kraft, Peter
-
Liang, Liming
-
Sun, Qi
-
Franks, Paul W.
-
Manson, Jo Ann E ...
-
Willet, Walter C ...
-
Florez, Jose C.
-
Hu, Frank B.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
PLoS Medicine
- Av lärosätet
-
Lunds universitet