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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 09762naa a2202029 4500 | |
| 001 | oai:lup.lub.lu.se:c54994f5-98b3-4202-a320-7ad754c20934 | |
| 003 | SwePub | |
| 008 | 160401s2005 | |||||||||||000 ||eng| | |
| 009 | oai:gup.ub.gu.se/113198 | |
| 024 | 7 | a https://lup.lub.lu.se/record/11320842 URI |
| 024 | 7 | a https://doi.org/10.1001/jama.294.14.17992 DOI |
| 024 | 7 | a https://gup.ub.gu.se/publication/1131982 URI |
| 040 | a (SwePub)lud (SwePub)gu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a for2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Danesh, John4 aut |
| 245 | 1 0 | a Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis |
| 264 | 1 | b American Medical Association (AMA),c 2005 |
| 520 | a CONTEXT: Plasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke. OBJECTIVE: To assess the relationships of fibrinogen levels with risk of major vascular and with risk of nonvascular outcomes based on individual participant data. DATA SOURCES: Relevant studies were identified by computer-assisted searches, hand searches of reference lists, and personal communication with relevant investigators. STUDY SELECTION: All identified prospective studies were included with information available on baseline fibrinogen levels and details of subsequent major vascular morbidity and/or cause-specific mortality during at least 1 year of follow-up. Studies were excluded if they recruited participants on the basis of having had a previous history of cardiovascular disease; participants with known preexisting CHD or stroke were excluded. DATA EXTRACTION: Individual records were provided on each of 154,211 participants in 31 prospective studies. During 1.38 million person-years of follow-up, there were 6944 first nonfatal myocardial infarctions or stroke events and 13,210 deaths. Cause-specific mortality was generally available. Analyses involved proportional hazards modeling with adjustment for confounding by known cardiovascular risk factors and for regression dilution bias. DATA SYNTHESIS: Within each age group considered (40-59, 60-69, and > or =70 years), there was an approximately log-linear association with usual fibrinogen level for the risk of any CHD, any stroke, other vascular (eg, non-CHD, nonstroke) mortality, and nonvascular mortality. There was no evidence of a threshold within the range of usual fibrinogen level studied at any age. The age- and sex- adjusted hazard ratio per 1-g/L increase in usual fibrinogen level for CHD was 2.42 (95% confidence interval [CI], 2.24-2.60); stroke, 2.06 (95% CI, 1.83-2.33); other vascular mortality, 2.76 (95% CI, 2.28-3.35); and nonvascular mortality, 2.03 (95% CI, 1.90-2.18). The hazard ratios for CHD and stroke were reduced to about 1.8 after further adjustment for measured values of several established vascular risk factors. In a subset of 7011 participants with available C-reactive protein values, the findings for CHD were essentially unchanged following additional adjustment for C-reactive protein. The associations of fibrinogen level with CHD or stroke did not differ substantially according to sex, smoking, blood pressure, blood lipid levels, or several features of study design. CONCLUSIONS: In this large individual participant meta-analysis, moderately strong associations were found between usual plasma fibrinogen level and the risks of CHD, stroke, other vascular mortality, and nonvascular mortality in a wide range of circumstances in healthy middle-aged adults. Assessment of any causal relevance of elevated fibrinogen levels to disease requires additional research. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a Adult | |
| 653 | a Aged | |
| 653 | a *Cause of Death | |
| 653 | a Coronary Disease/*blood/*epidemiology | |
| 653 | a Fibrinogen/*metabolism | |
| 653 | a Humans | |
| 653 | a Middle Aged | |
| 653 | a Myocardial Infarction/blood/epidemiology | |
| 653 | a Proportional Hazards Models | |
| 653 | a Risk | |
| 653 | a Stroke/blood/*epidemiology | |
| 653 | a Vascular Diseases/blood/epidemiology | |
| 700 | 1 | a Lewington, Sarah4 aut |
| 700 | 1 | a Thompson, Simon G4 aut |
| 700 | 1 | a Lowe, Gordon D O4 aut |
| 700 | 1 | a Collins, Rory4 aut |
| 700 | 1 | a Kostis, J B4 aut |
| 700 | 1 | a Wilson, A C4 aut |
| 700 | 1 | a Rosengren, Annika,d 1951u Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute4 aut0 (Swepub:gu)xrosan |
| 700 | 1 | a Wu, K4 aut |
| 700 | 1 | a Benderly, M4 aut |
| 700 | 1 | a Goldbourt, U4 aut |
| 700 | 1 | a Willeit, J4 aut |
| 700 | 1 | a Kiechl, S4 aut |
| 700 | 1 | a Yarnell, J W G4 aut |
| 700 | 1 | a Sweetnam, P M4 aut |
| 700 | 1 | a Elwood, P C4 aut |
| 700 | 1 | a Cushman, M4 aut |
| 700 | 1 | a Psaty, B M4 aut |
| 700 | 1 | a Tracy, R P4 aut |
| 700 | 1 | a Tybjærg-Hansen, A4 aut |
| 700 | 1 | a Haverkate, F4 aut |
| 700 | 1 | a de Maat, M P M4 aut |
| 700 | 1 | a Thompson, S G4 aut |
| 700 | 1 | a Fowkes, F G R4 aut |
| 700 | 1 | a Lee, A J4 aut |
| 700 | 1 | a Smith, F B4 aut |
| 700 | 1 | a Salomaa, V4 aut |
| 700 | 1 | a Harald, K4 aut |
| 700 | 1 | a Rasi, V4 aut |
| 700 | 1 | a Vahtera, E4 aut |
| 700 | 1 | a Jousilahti, P4 aut |
| 700 | 1 | a Pekkanen, J4 aut |
| 700 | 1 | a D’Agostino, R4 aut |
| 700 | 1 | a Kannel, W B4 aut |
| 700 | 1 | a Wilson, P W F4 aut |
| 700 | 1 | a Tofler, G4 aut |
| 700 | 1 | a Arocha-Piñango, C L4 aut |
| 700 | 1 | a Rodriguez-Larralde, A4 aut |
| 700 | 1 | a Nagy, E4 aut |
| 700 | 1 | a Mijares, M4 aut |
| 700 | 1 | a Espinosa, R4 aut |
| 700 | 1 | a Rodriquez-Roa, E4 aut |
| 700 | 1 | a Ryder, E4 aut |
| 700 | 1 | a Diez-Ewald, M P4 aut |
| 700 | 1 | a Campos, G4 aut |
| 700 | 1 | a Fernandez, V4 aut |
| 700 | 1 | a Torres, E4 aut |
| 700 | 1 | a Coll, E4 aut |
| 700 | 1 | a Marchioli, R4 aut |
| 700 | 1 | a Valagussa, F4 aut |
| 700 | 1 | a Rosengren, A4 aut |
| 700 | 1 | a Wilhelmsen, L4 aut |
| 700 | 1 | a Lappas, Georg,d 19624 aut |
| 700 | 1 | a Eriksson, H4 aut |
| 700 | 1 | a Cremer, P4 aut |
| 700 | 1 | a Nagel, D4 aut |
| 700 | 1 | a Curb, J D4 aut |
| 700 | 1 | a Rodriguez, B4 aut |
| 700 | 1 | a Yano, K4 aut |
| 700 | 1 | a Salonen, J T4 aut |
| 700 | 1 | a Nyyssönen, K4 aut |
| 700 | 1 | a Tuomainen, T-P4 aut |
| 700 | 1 | a Hedblad, Bou Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-bhe |
| 700 | 1 | a Lind, P4 aut |
| 700 | 1 | a Loewel, H4 aut |
| 700 | 1 | a Koenig, W4 aut |
| 700 | 1 | a Meade, T W4 aut |
| 700 | 1 | a Cooper, J A4 aut |
| 700 | 1 | a De Stavola, B4 aut |
| 700 | 1 | a Knottenbelt, C4 aut |
| 700 | 1 | a Miller, G J4 aut |
| 700 | 1 | a Cooper, J A4 aut |
| 700 | 1 | a Bauer, K A4 aut |
| 700 | 1 | a Rosenberg, R D4 aut |
| 700 | 1 | a Sato, S4 aut |
| 700 | 1 | a Kitamura, A4 aut |
| 700 | 1 | a Naito, Y4 aut |
| 700 | 1 | a Iso, H4 aut |
| 700 | 1 | a Salomaa, V4 aut |
| 700 | 1 | a Rasi, V4 aut |
| 700 | 1 | a Vahtera, E4 aut |
| 700 | 1 | a Jousilahti, P4 aut |
| 700 | 1 | a Palosuo, T4 aut |
| 700 | 1 | a Ducimetiere, P4 aut |
| 700 | 1 | a Amouyel, P4 aut |
| 700 | 1 | a Arveiler, D4 aut |
| 700 | 1 | a Evans, A E4 aut |
| 700 | 1 | a Ferrieres, J4 aut |
| 700 | 1 | a Juhan-Vague, I4 aut |
| 700 | 1 | a Bingham, A4 aut |
| 700 | 1 | a Schulte, H4 aut |
| 700 | 1 | a Assmann, G4 aut |
| 700 | 1 | a Cantin, B4 aut |
| 700 | 1 | a Lamarche, B4 aut |
| 700 | 1 | a Després, J-P4 aut |
| 700 | 1 | a Dagenais, G R4 aut |
| 700 | 1 | a Tunstall-Pedoe, H4 aut |
| 700 | 1 | a Woodward, M4 aut |
| 700 | 1 | a Ben-Shlomo, Y4 aut |
| 700 | 1 | a Davey Smith, G4 aut |
| 700 | 1 | a Palmieri, V4 aut |
| 700 | 1 | a Yeh, J L4 aut |
| 700 | 1 | a Meade, T W4 aut |
| 700 | 1 | a Rudnicka, A4 aut |
| 700 | 1 | a Knottenbelt, C4 aut |
| 700 | 1 | a Cooper, J A4 aut |
| 700 | 1 | a Ridker, P4 aut |
| 700 | 1 | a Rodeghiero, F4 aut |
| 700 | 1 | a Tosetto, A4 aut |
| 700 | 1 | a Shepherd, J4 aut |
| 700 | 1 | a Ford, I4 aut |
| 700 | 1 | a Robertson, M4 aut |
| 700 | 1 | a Brunner, E4 aut |
| 700 | 1 | a Shipley, M4 aut |
| 700 | 1 | a Feskens, E J M4 aut |
| 700 | 1 | a Kromhout., D4 aut |
| 700 | 1 | a Dickinson, A4 aut |
| 700 | 1 | a Ireland, B4 aut |
| 700 | 1 | a Juzwishin, K4 aut |
| 700 | 1 | a Kaptoge, S4 aut |
| 700 | 1 | a Memon, A4 aut |
| 700 | 1 | a Sarwar, N4 aut |
| 700 | 1 | a Walker, M4 aut |
| 700 | 1 | a Wheeler, J4 aut |
| 700 | 1 | a White, I4 aut |
| 700 | 1 | a Wood, A4 aut |
| 700 | 1 | a Brennan, P4 aut |
| 700 | 1 | a Chambless, L4 aut |
| 700 | 1 | a Hense, H W4 aut |
| 700 | 1 | a Levy, D4 aut |
| 710 | 2 | a Göteborgs universitetb Hjärt-kärlinstitutionen4 org |
| 773 | 0 | t JAMA: The Journal of the American Medical Associationd : American Medical Association (AMA)g 294:14, s. 1799-1809q 294:14<1799-1809x 1538-3598x 0098-7484 |
| 773 | 0 | t JAMAd : American Medical Association (AMA)g 294:14, s. 1799-1809q 294:14<1799-1809x 0098-7484 |
| 856 | 4 | u http://dx.doi.org/10.1001/jama.294.14.1799y FULLTEXT |
| 856 | 4 | u https://researchonline.lshtm.ac.uk/id/eprint/12821/1/Plasma%20Fibrinogen%20Level%20and%20the%20Risk%20of%20Major%20Cardiovascular%20Diseases%20and%20Nonvascular%20Mortality.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1132084 |
| 856 | 4 8 | u https://doi.org/10.1001/jama.294.14.1799 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/113198 |
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