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The use of a recomb...
The use of a recombinant lentiviral vector for ex vivo gene transfer into the rat CNS
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- Englund, Ulrica (författare)
- Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine,Lund University, Sweden
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- Ericson, Cecilia (författare)
- Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine,Lund University, Sweden
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- Rosenblad, Carl (författare)
- NsGene A/S, Denmark
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- Mandel, Ronald J. (författare)
- University of Florida College of Medicine, USA
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- Trono, Didier (författare)
- University of Geneva Medical School, Switzerland
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- Wictorin, Klas (författare)
- Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine,Lund University, Sweden
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- Lundberg, Cecilia (författare)
- Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine,Lund University, Sweden
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2000
- 2000
- Engelska 5 s.
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Ingår i: NeuroReport. - : Lippincott Williams & Wilkins. - 0959-4965 .- 1473-558X. ; 11:18, s. 3973-3977
- Relaterad länk:
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A major obstacle in ex vivo gene transfer has been the loss of transgene expression soon after implantation of the grafted transduced cells. Recently, a lentiviral vector system has been developed which has proven to express high levels of transgenes in vivo after direct injection into the tissue. In this study, we have investigated the use of such a vector for ex vivo gene transfer to the brain. A number of neural cell types were found to be permissive to transduction by the lentiviral vector in vitro and a majority of them expressed the transgene after transplantation to the rat brain. Transgene expression was detected up to 8 weeks post-grafting. These findings suggest that recombinant lentiviral vectors may be used for further development of ex vivo gene therapy protocols to the CNS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Ex vivo gene transfer
- Green fluorescent protein
- Lentiviral vector
- Biomedical Sciences
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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