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氨曲南竞争性抑制NDM-1对β-内酰胺...
氨曲南竞争性抑制NDM-1对β-内酰胺类抗生素的水解
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- Wang, Xi (författare)
- Shanxi University
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- Li, Binchun (författare)
- Shanxi University
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- Zhang, Sheng (författare)
- Shanxi University
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- Xie, Bin (författare)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Wu, Changxin (författare)
- Shanxi University
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- Li, Shenwei (författare)
- Shanghai International Travel Healthcare Center
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- Meng, Qinglai (författare)
- Shanxi University
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(creator_code:org_t)
- 2019
- 2019
- Kinesiska.
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Ingår i: Journal of Shanxi University (Natural Science Edition). ; :2021-01
- Relaterad länk:
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http://cnki.nbsti.ne...
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Abstract
Ämnesord
Stäng
- We investigated the effect of Aztreonam on hydrolysis of β-lactam antibiotics by MBL using New Delhi Metallo-β-lactamase-1(NDM-1) as a model. The results showed that Aztreonam significantly inhibited hydrolysis of Nitrocefin and Meropenem by soluble NDM-1, but also inhibited hydrolysis of Penicillin G by CPG beads immobilized NDM-1(NDM-1 beads). Moreover, in spite of extensive washing for multiple times, the activity to hydrolyze Penicillin G by the Aztreoman pre-treated NDM-1 beads was just partially recovered. These data suggest that Aztreonam can covalently and stably bind on NDM-1, thus efficiently inhibiting hydrolysis of other kinds of β-lactam antibiotics by NDM-1 in a competitive way.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Aztreonam
- NDM-1
- metal-β-lactamase
- Superbug
- Antimicrobial resistance
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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