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TRIM22 genotype is ...
TRIM22 genotype is not associated with markers of disease progression in children with HIV-1 infection
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- Boswell, Michael T. (författare)
- University of Oxford
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- Yindom, Louis Marie (författare)
- University of Oxford
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- Hameiri-Bowen, Dan (författare)
- University of Oxford
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- McHugh, Grace (författare)
- Biomedical Research and Training Institut
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- Dauya, Ethel (författare)
- Biomedical Research and Training Institut
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- Bandason, Tsitsi (författare)
- Biomedical Research and Training Institut
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- Mujuru, Hilda (författare)
- University of Zimbabwe
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- Esbjörnsson, Joakim (författare)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,University of Oxford
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- Ferrand, Rashida A. (författare)
- London School of Hygiene and Tropical Medicine
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- Rowland-Jones, Sarah (författare)
- University of Oxford
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(creator_code:org_t)
- 2021
- 2021
- Engelska 6 s.
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Ingår i: AIDS (London, England). - 1473-5571. ; 35:15, s. 2445-2450
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- OBJECTIVE: Untreated perinatal HIV-1 infection is often associated with rapid disease progression in children with HIV (CWH), characterized by high viral loads and early mortality. TRIM22 is a host restriction factor, which directly inhibits HIV-1 transcription, and its genotype variation is associated with disease progression in adults. We tested the hypothesis that TRIM22 genotype is associated with disease progression in CWH. DESIGN: ART-naive CWH, aged 6-16 years, were recruited from primary care clinics in Harare, Zimbabwe. We performed a candidate gene association study of TRIM22 genotype and haplotypes with markers of disease progression and indicators of advanced disease. METHODS: TRIM22 exons three and four were sequenced by Sanger sequencing and single nucleotide polymorphisms were associated with markers of disease progression (CD4+ T-cell count and HIV viral load) and clinical indicators of advanced HIV disease (presence of stunting and chronic diarrhoea). Associations were tested using multivariate linear and logistic regression models. RESULTS: A total of 241 children, median age 11.4 years, 50% female, were included. Stunting was present in 16% of participants. Five SNPs were analyzed including rs7935564, rs2291842, rs78484876, rs1063303 and rs61735273. The median CD4+ count was 342 (IQR: 195-533) cells/μl and median HIV-1 viral load 34 199 (IQR: 8211-90 662) IU/ml. TRIM22 genotype and haplotypes were not associated with CD4+ T-cell count, HIV-1 viral load, stunting or chronic diarrhoea. CONCLUSION: TRIM22 genotype was not associated with markers of HIV disease progression markers or advanced disease in CWH.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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Boswell, Michael ...
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Yindom, Louis Ma ...
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Hameiri-Bowen, D ...
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McHugh, Grace
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Dauya, Ethel
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Bandason, Tsitsi
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visa fler...
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Mujuru, Hilda
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Esbjörnsson, Joa ...
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Ferrand, Rashida ...
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Rowland-Jones, S ...
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MEDICIN OCH HÄLS ...
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AIDS (London, En ...
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Lunds universitet