Sökning: onr:"swepub:oai:lup.lub.lu.se:c61e42f2-cf47-4ec3-a07e-0008d4cffc4c" >
Risk factors for ca...
Risk factors for cancers of unknown primary site: Results from the prospective EPIC cohort
-
Kaaks, Rudolf (författare)
-
Sookthai, Disorn (författare)
-
- Hemminki, Kari (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups
-
visa fler...
-
Kraemer, Alwin (författare)
-
Boeing, Heiner (författare)
-
- Wirfält, Elisabet (författare)
- Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups
-
- Weiderpass, Elisabete (författare)
- Karolinska Institutet
-
Overvad, Kim (författare)
-
Tjonneland, Anne (författare)
-
Olsen, Anja (författare)
-
Peeters, Petra H. (författare)
-
Bueno-de-Mesquita, H. B. (As) (författare)
-
Panico, Salvatore (författare)
-
Pala, Valeria (författare)
-
Vineis, Paolo (författare)
-
Ramon Quiros, J. (författare)
-
Ardanaz, Eva (författare)
-
Sanchez, Maria-Jose (författare)
-
Chirlaque, Maria-Dolores (författare)
-
Larranaga, Nerea (författare)
-
Brennan, Paul (författare)
-
Trichopoulos, Dimitrios (författare)
-
Trichopoulou, Antonia (författare)
-
Lagiou, Pagona (författare)
-
- Hallmans, Göran (författare)
- Umeå universitet,Näringsforskning
-
Khaw, Kay-Tee (författare)
-
Key, Timothy J. (författare)
-
Riboli, Elio (författare)
-
Canzian, Federico (författare)
-
visa färre...
-
(creator_code:org_t)
- 2014-04-10
- 2014
- Engelska.
-
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 135:10, s. 2475-2481
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://onlinelibrar...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- Cancer of unknown primary site (CUP) may be called an orphan disease, as it is diagnosed when metastases are detected while the primary tumor typically remains undetected, and because little research has been done on its primary causes. So far, few epidemiological studies, if any, have addressed possible risk factors for CUP. We analyzed data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (N=476,940). During prospective follow-up, a total of 651 cases of incident cases of CUP were detected (ICD-O-2 code C809). Proportional hazards models were conducted to examine the associations of lifetime history of smoking habits, alcohol consumption, levels of education and anthropometric indices of adiposity with risk of being diagnosed with CUP. Risk of being diagnosed with CUP was strongly related to smoking, with a relative risk of 3.66 [95% C.I., 2.24-5.97] for current, heavy smokers (26+ cigarettes/day) compared to never smokers (adjusted for alcohol consumption, body mass index, waist circumference and level of education) and a relative risk of 5.12 [3.09-8.47] for cases with CUP who died within 12 months. For alcohol consumption and level of education, weaker associations were observed but attenuated and no longer statistically significant after adjusting for smoking and indices of obesity. Finally, risk of CUP was increased by approximately 30 per cent for subjects in the highest versus lowest quartiles of waist circumference. Our analyses provide further documentation, in addition to autopsy studies, that a substantial proportion of cancers of unknown primary site may have their origin in smoking-related tumors, in particular. What's new? When cancer appears as metastatic disease but no primary tumor can be observed, it's called cancer of unknown primary site. Little is known about the risk factors for this type of cancer. This study analyzed data from a European cohort and discovered a strong association between smoking and these cancers. Other risk factors they identified were drinking alcohol and being fat. This is the first epidemiological study of these type of cancers, and it strengthens the observations from autopsy studies that many of these cancers of unknown primary site stem from smoking-related tumors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- cancer of unknown primary site (CUP)
- prospective cohort study
- smoking
- alcohol
- obesity
- waist circumference
- cancer of unknown primary site (CUP)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Kaaks, Rudolf
-
Sookthai, Disorn
-
Hemminki, Kari
-
Kraemer, Alwin
-
Boeing, Heiner
-
Wirfält, Elisabe ...
-
visa fler...
-
Weiderpass, Elis ...
-
Overvad, Kim
-
Tjonneland, Anne
-
Olsen, Anja
-
Peeters, Petra H ...
-
Bueno-de-Mesquit ...
-
Panico, Salvator ...
-
Pala, Valeria
-
Vineis, Paolo
-
Ramon Quiros, J.
-
Ardanaz, Eva
-
Sanchez, Maria-J ...
-
Chirlaque, Maria ...
-
Larranaga, Nerea
-
Brennan, Paul
-
Trichopoulos, Di ...
-
Trichopoulou, An ...
-
Lagiou, Pagona
-
Hallmans, Göran
-
Khaw, Kay-Tee
-
Key, Timothy J.
-
Riboli, Elio
-
Canzian, Federic ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Näringslära
- Artiklar i publikationen
-
International Jo ...
- Av lärosätet
-
Lunds universitet
-
Karolinska Institutet
-
Umeå universitet