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Interaction Between...
Interaction Between Overweight and Genotypes of HLA, TCF7L2, and FTO in Relation to the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes
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- Hjort, Rebecka (författare)
- Karolinska Institutet,Karolinska Institute
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- Löfvenborg, Josefin E. (författare)
- Karolinska Institutet,Karolinska Institute
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- Ahlqvist, Emma (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Alfredsson, Lars (författare)
- Karolinska Institutet,Karolinska Institute
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- Andersson, Tomas (författare)
- Karolinska Institutet,Stockholm County Council,Karolinska Institute
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- Grill, Valdemar (författare)
- Norwegian University of Science and Technology
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki
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- Sørgjerd, Elin P. (författare)
- Norwegian University of Science and Technology
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- Tuomi, Tiinamaija (författare)
- University of Helsinki,Folkhälsan Research Center,Helsinki University Central Hospital
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- Åsvold, Bjørn Olav (författare)
- St. Olav’s University Hospital,Norwegian University of Science and Technology
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- Carlsson, Sofia (författare)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- 2019-05-24
- 2019
- Engelska 12 s.
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 104:10, s. 4815-4826
- Relaterad länk:
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http://dx.doi.org/10...
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https://academic.oup...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: We investigated potential interactions between body mass index (BMI) and genotypes of human leukocyte antigen (HLA), TCF7L2-rs7903146, and FTO-rs9939609 in relation to the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes. METHODS: We pooled data from two population-based studies: (i) a Swedish study with incident cases of LADA [positive for glutamic acid decarboxylase autoantibodies (GADA); n = 394) and type 2 diabetes (negative for GADA; n = 1290) and matched controls without diabetes (n = 2656) and (ii) a prospective Norwegian study that included incident cases of LADA (n = 131) and type 2 diabetes (n = 1901) and 886,120 person-years of follow-up. Analyses were adjusted for age, sex, physical activity, and smoking. Interaction between overweight (BMI ≥ 25 kg/m2) and HLA/TCF7L2/FTO high-risk genotypes was assessed by attributable proportion due to interaction (AP). RESULTS: The combination of overweight and high-risk genotypes of HLA, TCF7L2, and FTO was associated with pooled relative risk (RRpooled) of 7.59 (95% CI, 5.27 to 10.93), 2.65 (95% CI, 1.97 to 3.56), and 2.21 (95% CI, 1.60 to 3.07), respectively, for LADA, compared with normal-weight individuals with low/intermediate genetic risk. There was a significant interaction between overweight and HLA (AP, 0.29; 95% CI, 0.10 to 0.47), TCF7L2 (AP, 0.31; 95% CI, 0.09 to 0.52), and FTO (AP, 0.38; 95% CI, 0.15 to 0.61). The highest risk of LADA was seen in overweight individuals homozygous for the DR4 genotype [RR, 26.76 (95% CI, 15.42 to 46.43); AP, 0.58 (95% CI, 0.32 to 0.83) (Swedish data)]. Overweight and TCF7L2 also significantly interacted in relation to type 2 diabetes (AP, 0.26; 95% CI, 0.19 to 0.33), but no interaction was observed with high-risk genotypes of HLA or FTO. CONCLUSIONS: Overweight interacts with HLA high-risk genotypes but also with genes associated with type 2 diabetes in the promotion of LADA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- ANDIS
- diabetes
- diabetics
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Hjort, Rebecka
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Löfvenborg, Jose ...
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Ahlqvist, Emma
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Alfredsson, Lars
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Andersson, Tomas
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Grill, Valdemar
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visa fler...
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Groop, Leif
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Sørgjerd, Elin P ...
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Tuomi, Tiinamaij ...
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Åsvold, Bjørn Ol ...
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Carlsson, Sofia
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visa färre...
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Lunds universitet
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Karolinska Institutet