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T-cell and B-cell p...
T-cell and B-cell perturbations are similar in ART-naive HIV-1 and HIV-1/2 dually infected patients
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- Hønge, Bo L. (författare)
- Bandim Health Project,Aarhus University Hospital
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- Petersen, Mikkel S. (författare)
- Aarhus University Hospital
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- Jespersen, Sanne (författare)
- Bandim Health Project,Aarhus University Hospital
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- Medina, Candida (författare)
- Ministry of Health, Guinea-Bissau
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- Té, David D.S. (författare)
- Ministry of Health, Guinea-Bissau
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- Kjerulff, Bertram (författare)
- Aarhus University Hospital
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- Jensen, Mads M. (författare)
- Bandim Health Project,Aarhus University Hospital
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- Steiniche, Ditte (författare)
- Aarhus University Hospital,Bandim Health Project
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- Esbjörnsson, Joakim (författare)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,University of Oxford
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- Laursen, Alex L. (författare)
- Aarhus University Hospital
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- Wejse, Christian (författare)
- Aarhus University,Bandim Health Project,Aarhus University Hospital
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- Krarup, Henrik (författare)
- Aalborg University
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- Møller, Bjarne K. (författare)
- Aarhus University Hospital
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- Erikstrup, Christian (författare)
- Aarhus University Hospital
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(creator_code:org_t)
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- 2019
- 2019
- Engelska 11 s.
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Ingår i: AIDS. - 0269-9370. ; 33:7, s. 1143-1153
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: HIV-2 may slow progression of a subsequently acquired HIV-1 infection through cross-neutralizing antibodies and polyfunctional CD8 T cells. We hypothesized that HIV-1/2 dually infected patients compared with HIV-1-infected patients had more preserved immune maturation subsets and less immune activation of T and B cells. METHODS: ART-naive patients with HIV-1 (n = 83) or HIV-1/2 dual (n = 27) infections were included in this cross-sectional study at an HIV clinic in Guinea-Bissau. Peripheral blood mononuclear cells (PBMCs) were analyzed by flow cytometry according to T-cell maturation and activation, regulatory T-cell fraction, and B-cell maturation and activation. RESULTS: HIV-1/2 dually infected patients had lower levels of HIV-1 RNA compared with patients with HIV-1 infection, but the levels of total HIV RNA (HIV-1 and HIV-2) were similar in the two patient groups. T-cell maturation, and proportions of regulatory T cells (FoxP3+) were also similar in the two groups. HIV-1/2 dually infected patients had higher proportions of CD4 and CD8 T cells positive for the activation marker CD38, but there was no difference in other T-cell activation markers (CD28, CTLA-4, PD-1). HIV-1/2 dually infected patients also had higher proportions of IgM-only B cells and plasmablasts. CONCLUSION: HIV-1/2 was not associated with less immune perturbations than for HIV-1 infection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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AIDS
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- Av författaren/redakt...
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Hønge, Bo L.
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Petersen, Mikkel ...
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Jespersen, Sanne
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Medina, Candida
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Té, David D.S.
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Kjerulff, Bertra ...
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visa fler...
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Jensen, Mads M.
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Steiniche, Ditte
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Esbjörnsson, Joa ...
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Laursen, Alex L.
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Wejse, Christian
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Krarup, Henrik
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Møller, Bjarne K ...
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Erikstrup, Chris ...
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AIDS
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