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T-cell and B-cell p...
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Hønge, Bo L.Bandim Health Project,Aarhus University Hospital
(författare)
T-cell and B-cell perturbations are similar in ART-naive HIV-1 and HIV-1/2 dually infected patients
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:c9d4b383-e1d7-4403-afd6-05ec7e9fa586
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https://lup.lub.lu.se/record/c9d4b383-e1d7-4403-afd6-05ec7e9fa586URI
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https://doi.org/10.1097/QAD.0000000000002185DOI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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BACKGROUND: HIV-2 may slow progression of a subsequently acquired HIV-1 infection through cross-neutralizing antibodies and polyfunctional CD8 T cells. We hypothesized that HIV-1/2 dually infected patients compared with HIV-1-infected patients had more preserved immune maturation subsets and less immune activation of T and B cells. METHODS: ART-naive patients with HIV-1 (n = 83) or HIV-1/2 dual (n = 27) infections were included in this cross-sectional study at an HIV clinic in Guinea-Bissau. Peripheral blood mononuclear cells (PBMCs) were analyzed by flow cytometry according to T-cell maturation and activation, regulatory T-cell fraction, and B-cell maturation and activation. RESULTS: HIV-1/2 dually infected patients had lower levels of HIV-1 RNA compared with patients with HIV-1 infection, but the levels of total HIV RNA (HIV-1 and HIV-2) were similar in the two patient groups. T-cell maturation, and proportions of regulatory T cells (FoxP3+) were also similar in the two groups. HIV-1/2 dually infected patients had higher proportions of CD4 and CD8 T cells positive for the activation marker CD38, but there was no difference in other T-cell activation markers (CD28, CTLA-4, PD-1). HIV-1/2 dually infected patients also had higher proportions of IgM-only B cells and plasmablasts. CONCLUSION: HIV-1/2 was not associated with less immune perturbations than for HIV-1 infection.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Petersen, Mikkel S.Aarhus University Hospital
(författare)
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Jespersen, SanneBandim Health Project,Aarhus University Hospital
(författare)
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Medina, CandidaMinistry of Health, Guinea-Bissau
(författare)
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Té, David D.S.Ministry of Health, Guinea-Bissau
(författare)
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Kjerulff, BertramAarhus University Hospital
(författare)
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Jensen, Mads M.Bandim Health Project,Aarhus University Hospital
(författare)
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Steiniche, DitteAarhus University Hospital,Bandim Health Project
(författare)
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Esbjörnsson, JoakimLund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,University of Oxford(Swepub:lu)med-jes
(författare)
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Laursen, Alex L.Aarhus University Hospital
(författare)
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Wejse, ChristianAarhus University,Bandim Health Project,Aarhus University Hospital
(författare)
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Krarup, HenrikAalborg University
(författare)
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Møller, Bjarne K.Aarhus University Hospital
(författare)
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Erikstrup, ChristianAarhus University Hospital
(författare)
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Bandim Health ProjectAarhus University Hospital
(creator_code:org_t)
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Bissau HIV Cohort study group
Sammanhörande titlar
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Ingår i:AIDS33:7, s. 1143-11530269-9370
Internetlänk
Hitta via bibliotek
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AIDS
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Till lärosätets databas
- Av författaren/redakt...
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Hønge, Bo L.
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Petersen, Mikkel ...
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Jespersen, Sanne
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Medina, Candida
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Té, David D.S.
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Kjerulff, Bertra ...
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visa fler...
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Jensen, Mads M.
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Steiniche, Ditte
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Esbjörnsson, Joa ...
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Laursen, Alex L.
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Wejse, Christian
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Krarup, Henrik
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Møller, Bjarne K ...
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Erikstrup, Chris ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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AIDS
- Av lärosätet
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Lunds universitet