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Sökning: onr:"swepub:oai:lup.lub.lu.se:ca077dbb-ba78-42c9-a804-d554950b0bf2" > Mood Disorders in S...

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FältnamnIndikatorerMetadata
00006011naa a2200829 4500
001oai:lup.lub.lu.se:ca077dbb-ba78-42c9-a804-d554950b0bf2
003SwePub
008160401s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:131576623
0247 a https://lup.lub.lu.se/record/77907562 URI
0247 a https://doi.org/10.1002/art.391112 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1315766232 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Hanly, John G.4 aut
2451 0a Mood Disorders in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
264 c 2015-06-26
264 1b Wiley,c 2015
520 a ObjectiveTo examine the frequency, characteristics, and outcome of mood disorders, as well as clinical and autoantibody associations, in a multiethnic/racial, prospective inception cohort of patients with systemic lupus erythematosus (SLE). MethodsPatients were assessed annually for mood disorders (4 types, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) and 18 other neuropsychiatric events. Global disease activity scores (SLE Disease Activity Index 2000 [SLEDAI-2K]), damage scores (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]), and Short Form 36 subscales, mental and physical component summary scores were collected. Time to event, linear and ordinal regressions, and multi-state models were used as appropriate. ResultsAmong the 1,827 patients with SLE, 88.9% were female, and 48.9% were Caucasian. The mean SD age of the patients was 35.1 +/- 13.3 years, disease duration was 5.6 +/- 4.8 months, and the length of followup was 4.7 +/- 3.5 years. During the course of the study, 863 (47.2%) of the 1,827 patients had 1,627 neuropsychiatric events. Mood disorders occurred in 232 (12.7%) of 1,827 patients, and 98 (38.3%) of 256 mood disorder events were attributed to SLE. The estimated cumulative incidence of any mood disorder after 10 years was 17.7% (95% confidence interval 15.1, 20.2%). A greater risk of mood disorder was associated with concurrent neuropsychiatric events (P0.01), and a lower risk was associated with Asian race/ethnicity (P=0.01) and treatment with immunosuppressive drugs (P=0.003). Mood disorders were associated with lower mental health and mental component summary scores but not with the SLEDAI-2K, SDI, or lupus autoantibodies. Among the 232 patients with depression, 168 (72.4%) were treated with antidepressants. One hundred twenty-six (49.2%) of 256 mood disorders resolved in 117 (50.4%) of 232 patients. ConclusionMood disorders, the second most frequent neuropsychiatric event in patients with SLE, have a negative impact on health-related quality of life and improve over time. The lack of association with global SLE disease activity, cumulative organ damage, and lupus autoantibodies emphasizes the multifactorial etiology of mood disorders and a role for non-lupus-specific therapies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
7001 a Su, Li4 aut
7001 a Urowitz, Murray B.4 aut
7001 a Romero-Diaz, Juanita4 aut
7001 a Gordon, Caroline4 aut
7001 a Bae, Sang-Cheol4 aut
7001 a Bernatsky, Sasha4 aut
7001 a Clarke, Ann E.4 aut
7001 a Wallace, Daniel J.4 aut
7001 a Merrill, Joan T.4 aut
7001 a Isenberg, David A.4 aut
7001 a Rahman, Anisur4 aut
7001 a Ginzler, Ellen M.4 aut
7001 a Petri, Michelle4 aut
7001 a Bruce, Ian N.4 aut
7001 a Dooley, M. A.4 aut
7001 a Fortin, Paul4 aut
7001 a Gladman, Dafna D.4 aut
7001 a Sanchez-Guerrero, Jorge4 aut
7001 a Steinsson, Kristjan4 aut
7001 a Ramsey-Goldman, Rosalind4 aut
7001 a Khamashta, Munther A.4 aut
7001 a Aranow, Cynthia4 aut
7001 a Alarcon, Graciela S.4 aut
7001 a Fessler, Barri J.4 aut
7001 a Manzi, Susan4 aut
7001 a Nived, Olau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-oni
7001 a Sturfelt, Gunnaru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-gst
7001 a Zoma, Asad A.4 aut
7001 a van Vollenhoven, Ronald F.u Karolinska Institutet4 aut
7001 a Ramos-Casals, Manuel4 aut
7001 a Ruiz-Irastorza, Guillermo4 aut
7001 a Lim, S. Sam4 aut
7001 a Kalunian, Kenneth C.4 aut
7001 a Inanc, Murat4 aut
7001 a Kamen, Diane L.4 aut
7001 a Peschken, Christine A.4 aut
7001 a Jacobsen, Soren4 aut
7001 a Askanase, Anca4 aut
7001 a Theriault, Chris4 aut
7001 a Thompson, Kara4 aut
7001 a Farewell, Vernon4 aut
7102 a Reumatologi och molekylär skelettbiologib Sektion III4 org
7730 t Arthritis & Rheumatologyd : Wileyg 67:7, s. 1837-1847q 67:7<1837-1847x 2326-5191x 2326-5205
8564 u http://dx.doi.org/10.1002/art.39111y FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.39111
8564 8u https://lup.lub.lu.se/record/7790756
8564 8u https://doi.org/10.1002/art.39111
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:131576623

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