Sökning: onr:"swepub:oai:lup.lub.lu.se:ca077dbb-ba78-42c9-a804-d554950b0bf2" > Mood Disorders in S...
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000 | 06011naa a2200829 4500 | |
001 | oai:lup.lub.lu.se:ca077dbb-ba78-42c9-a804-d554950b0bf2 | |
003 | SwePub | |
008 | 160401s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:131576623 | |
024 | 7 | a https://lup.lub.lu.se/record/77907562 URI |
024 | 7 | a https://doi.org/10.1002/art.391112 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1315766232 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Hanly, John G.4 aut |
245 | 1 0 | a Mood Disorders in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study |
264 | c 2015-06-26 | |
264 | 1 | b Wiley,c 2015 |
520 | a ObjectiveTo examine the frequency, characteristics, and outcome of mood disorders, as well as clinical and autoantibody associations, in a multiethnic/racial, prospective inception cohort of patients with systemic lupus erythematosus (SLE). MethodsPatients were assessed annually for mood disorders (4 types, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) and 18 other neuropsychiatric events. Global disease activity scores (SLE Disease Activity Index 2000 [SLEDAI-2K]), damage scores (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]), and Short Form 36 subscales, mental and physical component summary scores were collected. Time to event, linear and ordinal regressions, and multi-state models were used as appropriate. ResultsAmong the 1,827 patients with SLE, 88.9% were female, and 48.9% were Caucasian. The mean SD age of the patients was 35.1 +/- 13.3 years, disease duration was 5.6 +/- 4.8 months, and the length of followup was 4.7 +/- 3.5 years. During the course of the study, 863 (47.2%) of the 1,827 patients had 1,627 neuropsychiatric events. Mood disorders occurred in 232 (12.7%) of 1,827 patients, and 98 (38.3%) of 256 mood disorder events were attributed to SLE. The estimated cumulative incidence of any mood disorder after 10 years was 17.7% (95% confidence interval 15.1, 20.2%). A greater risk of mood disorder was associated with concurrent neuropsychiatric events (P0.01), and a lower risk was associated with Asian race/ethnicity (P=0.01) and treatment with immunosuppressive drugs (P=0.003). Mood disorders were associated with lower mental health and mental component summary scores but not with the SLEDAI-2K, SDI, or lupus autoantibodies. Among the 232 patients with depression, 168 (72.4%) were treated with antidepressants. One hundred twenty-six (49.2%) of 256 mood disorders resolved in 117 (50.4%) of 232 patients. ConclusionMood disorders, the second most frequent neuropsychiatric event in patients with SLE, have a negative impact on health-related quality of life and improve over time. The lack of association with global SLE disease activity, cumulative organ damage, and lupus autoantibodies emphasizes the multifactorial etiology of mood disorders and a role for non-lupus-specific therapies. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
700 | 1 | a Su, Li4 aut |
700 | 1 | a Urowitz, Murray B.4 aut |
700 | 1 | a Romero-Diaz, Juanita4 aut |
700 | 1 | a Gordon, Caroline4 aut |
700 | 1 | a Bae, Sang-Cheol4 aut |
700 | 1 | a Bernatsky, Sasha4 aut |
700 | 1 | a Clarke, Ann E.4 aut |
700 | 1 | a Wallace, Daniel J.4 aut |
700 | 1 | a Merrill, Joan T.4 aut |
700 | 1 | a Isenberg, David A.4 aut |
700 | 1 | a Rahman, Anisur4 aut |
700 | 1 | a Ginzler, Ellen M.4 aut |
700 | 1 | a Petri, Michelle4 aut |
700 | 1 | a Bruce, Ian N.4 aut |
700 | 1 | a Dooley, M. A.4 aut |
700 | 1 | a Fortin, Paul4 aut |
700 | 1 | a Gladman, Dafna D.4 aut |
700 | 1 | a Sanchez-Guerrero, Jorge4 aut |
700 | 1 | a Steinsson, Kristjan4 aut |
700 | 1 | a Ramsey-Goldman, Rosalind4 aut |
700 | 1 | a Khamashta, Munther A.4 aut |
700 | 1 | a Aranow, Cynthia4 aut |
700 | 1 | a Alarcon, Graciela S.4 aut |
700 | 1 | a Fessler, Barri J.4 aut |
700 | 1 | a Manzi, Susan4 aut |
700 | 1 | a Nived, Olau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-oni |
700 | 1 | a Sturfelt, Gunnaru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-gst |
700 | 1 | a Zoma, Asad A.4 aut |
700 | 1 | a van Vollenhoven, Ronald F.u Karolinska Institutet4 aut |
700 | 1 | a Ramos-Casals, Manuel4 aut |
700 | 1 | a Ruiz-Irastorza, Guillermo4 aut |
700 | 1 | a Lim, S. Sam4 aut |
700 | 1 | a Kalunian, Kenneth C.4 aut |
700 | 1 | a Inanc, Murat4 aut |
700 | 1 | a Kamen, Diane L.4 aut |
700 | 1 | a Peschken, Christine A.4 aut |
700 | 1 | a Jacobsen, Soren4 aut |
700 | 1 | a Askanase, Anca4 aut |
700 | 1 | a Theriault, Chris4 aut |
700 | 1 | a Thompson, Kara4 aut |
700 | 1 | a Farewell, Vernon4 aut |
710 | 2 | a Reumatologi och molekylär skelettbiologib Sektion III4 org |
773 | 0 | t Arthritis & Rheumatologyd : Wileyg 67:7, s. 1837-1847q 67:7<1837-1847x 2326-5191x 2326-5205 |
856 | 4 | u http://dx.doi.org/10.1002/art.39111y FULLTEXT |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.39111 |
856 | 4 8 | u https://lup.lub.lu.se/record/7790756 |
856 | 4 8 | u https://doi.org/10.1002/art.39111 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131576623 |
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