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The transport mecha...
The transport mechanism of P4 ATPase lipid flippases
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- López-Marqués, Rosa L. (författare)
- University of Copenhagen
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- Gourdon, Pontus (författare)
- Lund University,Lunds universitet,Membranproteinstrukturbiologi,Forskargrupper vid Lunds universitet,Membrane Protein Structural Biology,Lund University Research Groups,University of Copenhagen
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- Günther Pomorski, Thomas (författare)
- Ruhr-University Bochum,University of Copenhagen
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- Palmgren, Michael (författare)
- University of Copenhagen
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(creator_code:org_t)
- 2020
- 2020
- Engelska 22 s.
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Ingår i: The Biochemical journal. - 0264-6021. ; 477:19, s. 3769-3790
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- P4 ATPase lipid flippases are ATP-driven transporters that translocate specific lipids from the exoplasmic to the cytosolic leaflet of biological membranes, thus establishing a lipid gradient between the two leaflets that is essential for many cellular processes. While substrate specificity, subcellular and tissue-specific expression, and physiological functions have been assigned to a number of these transporters in several organisms, the mechanism of lipid transport has been a topic of intense debate in the field. The recent publication of a series of structural models based on X-ray crystallography and cryo-EM studies has provided the first glimpse into how P4 ATPases have adapted the transport mechanism used by the cation-pumping family members to accommodate a substrate that is at least an order of magnitude larger than cations.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- autoinhibition
- CDC50 protein
- cryo-electron microscopy
- flippases
- lipid transport
- P4 ATPases
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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