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Persistent elevatio...
Persistent elevation of fibrosis biomarker cartilage oligomeric matrix protein following hepatitis C virus eradication
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- Andréasson, Kristofer (författare)
- Lund University,Lunds universitet,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Lund Systemic Sclerosis Research Group,Lund University Research Groups
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- Jönsson, Göran (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Hesselstrand, Roger (författare)
- Lund University,Lunds universitet,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Lund Systemic Sclerosis Research Group,Lund University Research Groups
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- Norrgren, Hans (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- Baishideng Publishing Group Inc. 2019
- 2019
- Engelska 5 s.
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Ingår i: World Journal of Hepatology. - : Baishideng Publishing Group Inc.. - 1948-5182. ; 11:3, s. 330-334
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.4...
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https://lup.lub.lu.s...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- Serum levels of cartilage oligomeric matrix protein (COMP) has been presented as a biomarker of liver fibrosis in several cross-sectional studies. COMP is also an essential mediator in carcinoma development and has also been associated with hepatocellular carcinoma. We present a prospective analysis of this biomarker in 38 patients with chronic hepatitis C who were subject to eradication therapy with direct acting antivirals. We confirm previous studies associating COMP elevation with liver cirrhosis. We also show how viral levels are correlated with COMP at baseline. In our prospective analysis, we report that successful eradication of hepatitis C results in improvement in liver stiffness and laboratory liver function tests at 1 year follow-up. In contrast, median COMP-levels remain unchanged during the study period. We conclude that the biomarker potential of COMP in the prospective evaluation of liver diseases, remains to be elucidated.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Cartilage oligomeric matrix protein
- Chronic
- Fibrosis
- Hepatitis C
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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