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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04424naa a2200445 4500 | |
| 001 | oai:lup.lub.lu.se:cbb279fc-87a0-4a88-b636-35c52a63b937 | |
| 003 | SwePub | |
| 008 | 161228s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/cbb279fc-87a0-4a88-b636-35c52a63b9372 URI |
| 024 | 7 | a https://doi.org/10.1017/S00332917160030322 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Kendler, K. S.u Virginia Commonwealth University4 aut0 (Swepub:lu)med-kek |
| 245 | 1 0 | a Social and economic consequences of alcohol use disorder : a longitudinal cohort and co-relative analysis |
| 264 | 1 | c 2017 |
| 300 | a 11 s. | |
| 520 | a Background: Although alcohol use disorder (AUD) is associated with future risk for psychosocial dysfunction, the degree to which this arises from a direct causal effect of AUD on functioning v. from correlated risk factors (also known as confounders) is less clearly established. Method: AUD was assessed from Swedish medical, criminal and pharmacy registries. In a large general population cohort, using Cox proportional hazard and regression models, we predicted from the onset of AUD four outcomes: early retirement, unemployment, social assistance, and individual income. We then examined the degree to which these associations were attenuated by relevant confounders as well as by the use of discordant cousin, half-sibling, full-sibling, and monozygotic twin pairs. Results: In males, AUD most strongly predicted social assistance [hazard ratio (HR) 8.27, 95% confidence interval (CI) 7.96–8.59], followed by early retirement (HR 5.63, 95% CI 5.53–5.72) and unemployment (HR 2.75, 95% CI 2.65–2.85). For income at age 50, AUD was associated with a decrease in income of 0.24 s.d.s (95% CI −0.25 to −0.23). Results were similar in females. Modest to moderate attenuation of these associations was seen in both sexes after the addition of relevant covariates. These associations were reduced but remained robust in discordant co-relative pairs, including monozygotic twins. Conclusions: Our results suggest that AUD has a causal impact on a range of measures reflective of psychosocial dysfunction. These findings provide strong support for the drift hypothesis. However, some of the associations between AUD and dysfunction appear to be non-causal and result from shared risk factors, many of which are likely familial. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Beroendelära0 (SwePub)303092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Substance Abuse0 (SwePub)303092 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 653 | a Alcohol use disorder | |
| 653 | a co-relative design | |
| 653 | a drift | |
| 653 | a early retirement | |
| 653 | a income | |
| 653 | a social assistance | |
| 653 | a unemployment | |
| 700 | 1 | a Ohlsson, H.u Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-heo |
| 700 | 1 | a Karriker-Jaffe, K. J.u Public Health Institute Oakland4 aut |
| 700 | 1 | a Sundquist, J.u Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-jsu |
| 700 | 1 | a Sundquist, K.u Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups4 aut0 (Swepub:lu)med-ksq |
| 710 | 2 | a Virginia Commonwealth Universityb Allmänmedicin och klinisk epidemiologi4 org |
| 773 | 0 | t Psychological Medicineg 47:5, s. 925-935q 47:5<925-935x 0033-2917 |
| 856 | 4 | u http://dx.doi.org/10.1017/S0033291716003032y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/cbb279fc-87a0-4a88-b636-35c52a63b937 |
| 856 | 4 8 | u https://doi.org/10.1017/S0033291716003032 |
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