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Interactive roles o...
Interactive roles of the cerebellum and striatum in sub-second and supra-second timing : Support for an initiation, continuation, adjustment, and termination (ICAT) model of temporal processing
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- Petter, Elijah A. (författare)
- Duke University
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- Lusk, Nicholas A. (författare)
- Duke University
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- Hesslow, Germund (författare)
- Lund University,Lunds universitet,Associativ inlärning,Forskargrupper vid Lunds universitet,Associative Learning,Lund University Research Groups
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- Meck, Warren H. (författare)
- Duke University
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska 17 s.
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Ingår i: Neuroscience and Biobehavioral Reviews. - : Elsevier BV. - 0149-7634. ; 71, s. 739-755
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The contributions of cortico-cerebellar and cortico-striatal circuits to timing and time perception have often been a point of contention. In this review we propose that the cerebellum principally functions to reduce variability, through the detection of stimulus onsets and the sub-division of longer durations, thus contributing to both sub-second and supra-second timing. This sensitivity of the cerebellum to stimulus dynamics and subsequent integration with motor control allows it to accurately measure intervals within a range of 100–2000 ms. For intervals in the supra-second range (e.g., >2000 ms), we propose that cerebellar output signals from the dentate nucleus pass through thalamic connections to the striatum, where cortico-thalamic-striatal circuits supporting higher-level cognitive functions take over. Moreover, the importance of intrinsic circuit dynamics as well as behavioral, neuroimaging, and lesion studies of the cerebellum and striatum are discussed in terms of a framework positing initiation, continuation, adjustment, and termination phases of temporal processing.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Degeneracy
- Interval timing
- Medium spiny neurons
- Neural oscillations
- Purkinje cells
- Striatal beat-frequency model
- Time perception
Publikations- och innehållstyp
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- ref (ämneskategori)
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