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Severe CTE and TDP-...
Severe CTE and TDP-43 pathology in a former professional soccer player with dementia : a clinicopathological case report and review of the literature
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- van Amerongen, Suzan (författare)
- Vrije Universiteit Amsterdam,Boston University
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- Kamps, Suzie (författare)
- Vrije Universiteit Amsterdam
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- Kaijser, Kyra K.M. (författare)
- Vrije Universiteit Amsterdam
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- Pijnenburg, Yolande A.L. (författare)
- Vrije Universiteit Amsterdam
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- Scheltens, Philip (författare)
- Vrije Universiteit Amsterdam
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- Teunissen, Charlotte E. (författare)
- Vrije Universiteit Amsterdam
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- Barkhof, Frederik (författare)
- Vrije Universiteit Amsterdam,University College London
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- Ossenkoppele, Rik (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
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- Rozemuller, Annemieke J.M. (författare)
- Vrije Universiteit Amsterdam
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- Stern, Robert A. (författare)
- Boston University
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Hoozemans, Jeroen J.M. (författare)
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- Vijverberg, Everard G.B. (författare)
- Vrije Universiteit Amsterdam
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Acta Neuropathologica Communications. - 2051-5960. ; 11:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In the last decades, numerous post-mortem case series have documented chronic traumatic encephalopathy (CTE) in former contact-sport athletes, though reports of CTE pathology in former soccer players are scarce. This study presents a clinicopathological case of a former professional soccer player with young-onset dementia. The patient experienced early onset progressive cognitive decline and developed dementia in his mid-50 s, after playing soccer for 12 years at a professional level. While the clinical picture mimicked Alzheimer’s disease, amyloid PET imaging did not provide evidence of elevated beta-amyloid plaque density. After he died in his mid-60 s, brain autopsy showed severe phosphorylated tau (p-tau) abnormalities fulfilling the neuropathological criteria for high-stage CTE, as well as astrocytic and oligodendroglial tau pathology in terms of tufted astrocytes, thorn-shaped astrocytes, and coiled bodies. Additionally, there were TAR DNA-binding protein 43 (TDP-43) positive cytoplasmic inclusions in the frontal lobe and hippocampus, and Amyloid Precursor Protein (APP) positivity in the axons of the white matter. A systematic review of the literature revealed only 13 other soccer players with postmortem diagnosis of CTE. Our report illustrates the complex clinicopathological correlation of CTE and the need for disease-specific biomarkers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Association football
- Biomarkers
- Chronic traumatic encephalopathy
- Neurodegeneration
- Repetitive head impacts
- Soccer
- Tauopathy
- Traumatic encephalopathy syndrome
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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van Amerongen, S ...
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Kamps, Suzie
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Kaijser, Kyra K. ...
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Pijnenburg, Yola ...
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Scheltens, Phili ...
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Teunissen, Charl ...
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visa fler...
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Barkhof, Frederi ...
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Ossenkoppele, Ri ...
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Rozemuller, Anne ...
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Stern, Robert A.
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Hoozemans, Jeroe ...
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Vijverberg, Ever ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Acta Neuropathol ...
- Av lärosätet
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Lunds universitet