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Sökning: onr:"swepub:oai:lup.lub.lu.se:ce0c9de5-4f8c-4c8b-b3a1-48ff1099c060" > Birth Weight Is Ass...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005076naa a2200529 4500
001oai:lup.lub.lu.se:ce0c9de5-4f8c-4c8b-b3a1-48ff1099c060
003SwePub
008230906s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/ce0c9de5-4f8c-4c8b-b3a1-48ff1099c0602 URI
0247 a https://doi.org/10.1161/JAHA.123.0302202 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Schuermans, Artu Massachusetts General Hospital,Broad Institute4 aut
2451 0a Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood
264 1c 2023
520 a BACKGROUND: High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic cells with preleu-kemic somatic mutations, predicts incident cardiovascular disease independent of traditional cardiovascular risk factors. Whether birth weight predicts development of CHIP later in life is unknown. METHODS AND RESULTS: A total of 221 047 adults enrolled in the UK Biobank with whole exome sequences and self-reported birth weight were analyzed. Of those, 22 030 (11.5%) had low (<2.5 kg) and 29 292 (14.7%) high birth weight (>4.0 kg). CHIP prevalence was higher among participants with low (6.0%, P=0.049) and high (6.3%, P<0.001) versus normal birth weight (5.7%, ref.). Multivariable-adjusted logistic regression analyses demonstrated that each 1-kg increase in birth weight was associated with a 3% increased risk of CHIP (odds ratio, 1.03 [95% CI, 1.00–1.06]; P=0.04), driven by a stronger association ob-served between birth weight and DNMT3A CHIP (odds ratio, 1.04 per 1-kg increase [95% CI, 1.01–1.08]; P=0.02). Mendelian randomization analyses supported a causal relationship of longer gestational age at delivery with DNMT3A CHIP. Multivariable Cox regression demonstrated that CHIP was independently and additively associated with incident cardiovascular disease or death across birth weight groups, with highest absolute risks in those with CHIP plus high or low birth weight. CONCLUSIONS: Higher birth weight is associated with increased risk of developing CHIP in midlife, especially DNMT3A CHIP. These findings identify a novel risk factor for CHIP and provide insights into the relationships among early-life environment, CHIP, cancer, and cardiovascular disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a birth weight
653 a cardiovascular disease
653 a clonal hematopoiesis
653 a early life
653 a genetics
7001 a Nakao, Tetsushiu Massachusetts General Hospital,Broad Institute,Brigham and Women's Hospital / Harvard Medical School4 aut
7001 a Ruan, Yunfengu Massachusetts General Hospital,Broad Institute4 aut
7001 a Koyama, Satoshiu Broad Institute,Massachusetts General Hospital4 aut0 (Swepub:lu)sa2525ko
7001 a Yu, Zhiu Massachusetts General Hospital,Broad Institute4 aut
7001 a Uddin, Md Mesbahu Massachusetts General Hospital,Broad Institute4 aut
7001 a Haidermota, Sarau Broad Institute,Massachusetts General Hospital4 aut
7001 a Hornsby, Whitneyu Massachusetts General Hospital,Broad Institute4 aut
7001 a Lewandowski, Adam J.u University of Oxford4 aut
7001 a Bick, Alexander G.u Vanderbilt University Medical Center4 aut
7001 a Niroula, Abhisheku Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Department of Laboratory Medicine,Faculty of Medicine,Broad Institute,Dana-Farber Cancer Institute4 aut0 (Swepub:lu)med-anu
7001 a Jaiswal, Siddharthau Stanford University School of Medicine4 aut
7001 a Ebert, Benjamin L.u Howard Hughes Medical Institute,Dana-Farber Cancer Institute4 aut
7001 a Natarajan, Pradeepu Harvard Medical School,Massachusetts General Hospital,Broad Institute4 aut
7001 a Honigberg, Michael C.u Harvard Medical School,Broad Institute,Massachusetts General Hospital4 aut
7102 a Massachusetts General Hospitalb Broad Institute4 org
7730 t Journal of the American Heart Associationg 12:13q 12:13x 2047-9980
8564 u http://dx.doi.org/10.1161/JAHA.123.030220x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/ce0c9de5-4f8c-4c8b-b3a1-48ff1099c060
8564 8u https://doi.org/10.1161/JAHA.123.030220

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