SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:lup.lub.lu.se:cfc4d048-2b7a-4de1-afa0-5e47845469f9"
 

Sökning: onr:"swepub:oai:lup.lub.lu.se:cfc4d048-2b7a-4de1-afa0-5e47845469f9" > The influence of th...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005467naa a2200625 4500
001oai:lup.lub.lu.se:cfc4d048-2b7a-4de1-afa0-5e47845469f9
003SwePub
008240506s2024 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/cfc4d048-2b7a-4de1-afa0-5e47845469f92 URI
0247 a https://doi.org/10.1016/j.jinorgbio.2024.1125732 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Durigon, Daniele C.u Federal University of Santa Catarina4 aut
2451 0a The influence of thioether-substituted ligands in dicopper(II) complexes : Enhancing oxidation and biological activities
264 1c 2024
520 a This paper describes the synthesis, structural analysis, as well as the magnetic and spectroscopic characterizations of three new dicopper(II) complexes with dinucleating phenol-based ligands containing different thioether donor substituents: aromatic (1), aliphatic (2) or thiophene (3). Temperature-dependent magnetometry reveals the presence of antiferromagnetic coupling for 1 and 3 (J = −2.27 cm−1 and -5.01 cm−1, respectively, H = -2JS1S2) and ferromagnetic coupling for 2 (J = 5.72 cm−1). Broken symmetry DFT calculations attribute this behavior to a major contribution from the dz2 orbitals for 1 and 3, and from the dx2-y2 orbitals for 2, along with the p orbitals of the oxygens. The bioinspired catalytic activities of these complexes related to catechol oxidase were studied using 3,5-di-tert-butylcatechol as substrate. The order of catalytic rates for the substrate oxidation follows the trend 1 > 2 > 3 with kcat of (90.79 ± 2.90) × 10−3 for 1, (64.21 ± 0.99) × 10−3 for 2 and (14.20 ± 0.32) × 10−3 s−1 for 3. The complexes also cleave DNA through an oxidative mechanism with minor-groove preference, as indicated by experimental and molecular docking assays. Antimicrobial potential of these highly active complexes has shown that 3 inhibits both Staphylococcus aureus bacterium and Epidermophyton floccosum fungus. Notably, the complexes were found to be nontoxic to normal cells but exhibited cytotoxicity against epidermoid carcinoma cells, surpassing the activity of the metallodrug cisplatin. This research shows the multifaceted properties of these complexes, making them promising candidates for various applications in catalysis, nucleic acids research, and antimicrobial activities.
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
650 7a NATURVETENSKAPx Kemix Fysikalisk kemi0 (SwePub)104022 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciencesx Physical Chemistry0 (SwePub)104022 hsv//eng
650 7a NATURVETENSKAPx Kemix Oorganisk kemi0 (SwePub)104042 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciencesx Inorganic Chemistry0 (SwePub)104042 hsv//eng
650 7a NATURVETENSKAPx Kemix Organisk kemi0 (SwePub)104052 hsv//swe
650 7a NATURAL SCIENCESx Chemical Sciencesx Organic Chemistry0 (SwePub)104052 hsv//eng
653 a Anticancer activity
653 a Antimicrobial activity
653 a Catecholase Activity
653 a Dicopper(II) complexes
653 a DNA cleavage
653 a Thioether ligands
7001 a Glitz, Vinícius A.u Federal University of Santa Catarina4 aut
7001 a Pimenta, Beatriz F.u Federal University of Santa Catarina4 aut
7001 a Guedes, Anderson M.V.u Federal University of Rio de Janeiro4 aut
7001 a Silva, João V.O.u State University of Maringá4 aut
7001 a Bella Cruz, Catarina C.4 aut
7001 a Andrade, Lídia M.u Federal University of Minas Gerais4 aut
7001 a Pereira-Maia, Elene C.u Federal University of Minas Gerais4 aut
7001 a Mikcha, Jane M.G.u State University of Maringá4 aut
7001 a Bella Cruz, Alexandre4 aut
7001 a Xavier, Fernando R.u State University Of Santa Catarina4 aut
7001 a Terenzi, Hernán F.u Federal University of Santa Catarina4 aut
7001 a Poneti, Giordanou Federal University of Rio de Janeiro,University of Tuscia4 aut
7001 a Ribeiro, Ronny R.u Federal University of Paraná4 aut
7001 a Nordlander, Ebbeu Lund University,Lunds universitet,Kemisk fysik,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,LU profilområde: Ljus och material,Lunds universitets profilområden,Chemical Physics,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas4 aut0 (Swepub:lu)ook1-eno
7001 a Caramori, Giovanni F.u Federal University of Santa Catarina4 aut
7001 a Bortoluzzi, Adailton J.u Federal University of Santa Catarina4 aut
7001 a Peralta, Rosely A.u Federal University of Santa Catarina4 aut
7102 a Federal University of Santa Catarinab Federal University of Rio de Janeiro4 org
7730 t Journal of Inorganic Biochemistryg 256q 256x 0162-0134
8564 u http://dx.doi.org/10.1016/j.jinorgbio.2024.112573y FULLTEXT
8564 8u https://lup.lub.lu.se/record/cfc4d048-2b7a-4de1-afa0-5e47845469f9
8564 8u https://doi.org/10.1016/j.jinorgbio.2024.112573

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy