Sökning: onr:"swepub:oai:lup.lub.lu.se:d33e85bd-8c4e-4f6b-9e8b-b1738df51076" > Health-related qual...
Fältnamn | Indikatorer | Metadata |
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000 | 03670naa a2200421 4500 | |
001 | oai:lup.lub.lu.se:d33e85bd-8c4e-4f6b-9e8b-b1738df51076 | |
003 | SwePub | |
008 | 160401s2000 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/11170192 URI |
024 | 7 | a https://doi.org/10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W2 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Hagell, Peteru Lund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Department of Health Sciences,Faculty of Medicine4 aut0 (Swepub:lu)neur-pha |
245 | 1 0 | a Health-related quality of life following bilateral intrastriatal transplantation in Parkinson's disease |
264 | 1 | c 2000 |
520 | a Intrastriatal transplantation of embryonic dopaminergic tissue is a new, experimental approach for the treatment of Parkinson's disease (PD). Clinical trials have shown longterm graft survival and therapeutically valuable improvements with decreased L-dopa dose and time spent in the "off"-phase, and reduced rigidity and hypokinesia. We have measured health-related quality of life (HRQoL) using the Nottingham Health Profile (NHP) in five patients subjected to bilateral transplantation in the caudate and putamen to explore the influence of intrastriatal grafts on HRQoL and the value of such measures in trials of restorative therapies. The results demonstrate improved HRQoL following transplantation, with individual patients showing striking improvements within different dimensions of the NHP as well as the NHP distress index (NHPD). The most pronounced improvements after grafting were observed for physical mobility along with emotional reactions and energy. These results indicate that intrastriatal transplantation of embryonic dopaminergic tissue can give rise to improvements within most areas of HRQoL, and that HRQoL measurements provide important information additional to that obtained by traditional, symptom-oriented assessment protocols. However, the optimal approach to HRQoL measurement in PD remains to be determined. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a Parkinson's disease | |
653 | a Transplantation | |
653 | a Health-related quality of life | |
653 | a Nottingham Health Profile | |
700 | 1 | a Crabb, L4 aut |
700 | 1 | a Pogarell, O4 aut |
700 | 1 | a Schrag, A4 aut |
700 | 1 | a Widner, Håkanu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)mphy-hwi |
700 | 1 | a Brooks, D J4 aut |
700 | 1 | a Oertel, W H4 aut |
700 | 1 | a Quinn, N P4 aut |
700 | 1 | a Lindvall, Olleu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-oli |
710 | 2 | a Institutionen för hälsovetenskaperb Medicinska fakulteten4 org |
773 | 0 | t Movement Disordersg 15:2, s. 224-229q 15:2<224-229x 0885-3185 |
856 | 4 | u http://dx.doi.org/10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-Wy FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/1117019 |
856 | 4 8 | u https://doi.org/10.1002/1531-8257(200003)15:2<224::AID-MDS1004>3.0.CO;2-W |
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