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Sökning: onr:"swepub:oai:lup.lub.lu.se:d35474ab-67c1-4f01-8a9b-db3f2291a1b6" > Leukocyte telomere ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005424naa a2200865 4500
001oai:lup.lub.lu.se:d35474ab-67c1-4f01-8a9b-db3f2291a1b6
003SwePub
008160401s2014 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:130135318
009oai:DiVA.org:umu-97595
0247 a https://lup.lub.lu.se/record/46153832 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-14-02472 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1301353182 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-975952 URI
040 a (SwePub)lud (SwePub)kid (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Campa, Daniele4 aut
2451 0a Leukocyte telomere length in relation to pancreatic cancer risk: a prospective study.
264 1c 2014
520 a Background: Several studies have examined leukocyte telomere length (LTL) as a possible predictor for cancer at various organ sites. The hypothesis originally motivating many of these studies was that shorter telomeres would be associated with an increase in cancer risk, the results of epidemiologic studies have been inconsistent, however, and suggested positive, negative, or null associations. Two studies have addressed the association of LTL in relation to pancreatic cancer risk and the results are contrasting. Methods: we measured LTL in a prospective study of 331 pancreatic cancer cases and 331 controls in the context of the European Prospective Investigation into Cancer and Nutrition (EPIC). Results: We observed that the mean LTL was higher in cases (0.59±0.20) than in controls (0.57±0.17), although this difference was not statistically significant (p=0.07), and a basic logistic regression model showed no association of LTL with pancreas cancer risk. When adjusting for levels of HbA1c and C-Peptide, however, there was a weakly positive association between longer LTL and pancreatic cancer risk , OR=1.13 (1.01-1.27). Additional analyses by cubic spline regression suggested a possible non-linear relationship between RTL and pancreatic cancer risk (P=0.022), with a statistically non-significant increase in risk at very low LTL, as well as a significant increase at high LTL. Conclusion: Taken together, the results from our study do not support LTL as a uniform and strong predictor of pancreatic cancer. Impact: The results of this manuscript can provide insights into telomere dynamics and highlight the complex relationship between LTL and pancreatic cancer risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Mergarten, Björn4 aut
7001 a De Vivo, Immaculata4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Racine, Antoine4 aut
7001 a Severi, Gianluca4 aut
7001 a Nieters, Alexandra4 aut
7001 a Katzke, Verena A4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Yiannakouris, Nikos4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Boeing, Heiner4 aut
7001 a Quiros, J Ramon4 aut
7001 a Duell, Eric J4 aut
7001 a Molina-Montes, Esther4 aut
7001 a Huerta, Jose-Maria4 aut
7001 a Ardanaz, Eva4 aut
7001 a Dorronsoro, Miren4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Wareham, Nick4 aut
7001 a Travis, Ruth C4 aut
7001 a Palli, Domenico4 aut
7001 a Pala, Valeria4 aut
7001 a Tumino, Rosario4 aut
7001 a Naccarati, Alessio4 aut
7001 a Panico, Salvatore4 aut
7001 a Vineis, Paolo4 aut
7001 a Riboli, Elio4 aut
7001 a Siddiq, Afshan4 aut
7001 a Bueno-de-Mesquita, H B4 aut
7001 a Peeters, Petra H M4 aut
7001 a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni
7001 a Sund, Malin,d 1972-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021
7001 a Ye, Weiminu Umeå universitet,Karolinska Institutet,Enheten för biobanksforskning,Karolinska Inst, Dept Med Epidemiol & Biostat4 aut
7001 a Lund, Eiliv4 aut
7001 a Jareid, Mie4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Duarte-Salles, Talita4 aut
7001 a Kong, So Y4 aut
7001 a Stepien, Magdalena4 aut
7001 a Canzian, Federico4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Wareham, Nicholas4 aut
7102 a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org
7730 t Cancer Epidemiology Biomarkers & Preventiong 23:11, s. 2447-2454q 23:11<2447-2454x 1538-7755x 1055-9965
8564 u http://www.ncbi.nlm.nih.gov/pubmed/25103821?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1158/1055-9965.EPI-14-0247y FULLTEXT
8564 8u https://lup.lub.lu.se/record/4615383
8564 8u https://doi.org/10.1158/1055-9965.EPI-14-0247
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:130135318
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-97595

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