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Acquisition, mainte...
Acquisition, maintenance and adaptation of invasion inhibitory antibodies against Plasmodium falciparum invasion ligands involved in immune evasion
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- Tijani, Muyideen K. (författare)
- University of Ibadan,Karolinska University Hospital
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- Babalola, Oluwatoyin A. (författare)
- University of Ibadan
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- Odaibo, Alex B. (författare)
- University of Ibadan
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- Anumudu, Chiaka I. (författare)
- University of Ibadan
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- Asinobi, Adanze O. (författare)
- University of Ibadan
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- Morenikeji, Olajumoke A. (författare)
- University of Ibadan
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- Asuzu, Michael C. (författare)
- University of Ibadan
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- Langer, Christine (författare)
- Macfarlane Burnet Institute for Medical Research and Public Health
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- Reiling, Linda (författare)
- Macfarlane Burnet Institute for Medical Research and Public Health
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- Beeson, James G. (författare)
- Macfarlane Burnet Institute for Medical Research and Public Health
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- Wahlgren, Mats (författare)
- Karolinska Institute
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- Nwuba, Roseangela I. (författare)
- University of Ibadan
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- Persson, Kristina E.M. (författare)
- Karolinska Institute,Lund University,Lunds universitet,Malaria och Babesia,Forskargrupper vid Lunds universitet,Malaria and Babesia,Lund University Research Groups
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(creator_code:org_t)
- 2017-08-07
- 2017
- Engelska.
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:8
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://journals.plo...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Erythrocyte-binding antigens (EBAs) and P. falciparum reticulocyte-binding homologue proteins (PfRhs) are two important protein families that can vary in expression and utilization by P. falciparum to evade inhibitory antibodies. We evaluated antibodies at repeated time-points among individuals living in an endemic region in Nigeria over almost one year against these vaccine candidates. Antibody levels against EBA140, EBA175, EBA181, PfRh2, PfRh4, and MSP2, were measured by ELISA. We also used parasites with disrupted EBA140, EBA175 and EBA181 genes to show that all these were targets of invasion inhibitory antibodies. However, antigenic targets of inhibitory antibodies were not stable and changed substantially over time in most individuals, independent of age. Antibodies levels measured by ELISA also varied within and between individuals over time and the antibodies against EBA181, PfRh2 and MSP2 declined more rapidly in younger individuals (15 years) compared with older (>15). The breadth of high antibody responses over time was more influenced by age than by the frequency of infection. High antibody levels were associated with a more stable invasion inhibitory response, which could indicate that during the long process of formation of immunity, many changes not only in levels but also in functional responses are needed. This is an important finding in understanding natural immunity against malaria, which is essential for making an efficacious vaccine.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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PLoS ONE
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Till lärosätets databas
- Av författaren/redakt...
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Tijani, Muyideen ...
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Babalola, Oluwat ...
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Odaibo, Alex B.
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Anumudu, Chiaka ...
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Asinobi, Adanze ...
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Morenikeji, Olaj ...
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visa fler...
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Asuzu, Michael C ...
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Langer, Christin ...
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Reiling, Linda
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Beeson, James G.
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Wahlgren, Mats
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Nwuba, Roseangel ...
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Persson, Kristin ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Immunologi inom ...
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PLoS ONE
- Av lärosätet
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Lunds universitet
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Karolinska Institutet