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Fatty Acid Profiles...
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Buduneli, N.
(författare)
Fatty Acid Profiles in Smokers with Chronic Periodontitis
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
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2010-11-01
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SAGE Publications,2011
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:d4cd9aa4-dd6c-466c-93fd-c4f5189bea4d
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https://lup.lub.lu.se/record/1791093URI
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https://doi.org/10.1177/0022034510380695DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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We hypothesized that tobacco smoke induces alterations to the 3-OH fatty acids present in lipid A in a manner consistent with a microflora of reduced inflammatory potential. Whole saliva samples and full-mouth clinical periodontal recordings were obtained from persons with (22 smokers; 15 nonsmokers) and without (14 smokers; 15 non-smokers) chronic periodontitis. Clear differences in the contributions of multiple saturated 3-OH fatty acid species were noted in the group with disease compared with healthy individuals. Increases in the long-chain fatty acids associated with anaerobic bacterial periodontopathogens, particularly 3-OH-C-i17.0 (146.7%, relative to controls), were apparent. Significant reductions in the 3-OH fatty acids associated with the consensus (high potency) enteric LPS structure (3-OH-C-12.0 and 3-OH-C-14.0; 33.3% and 15.8% reduction, respectively) were noted in smokers compared with non-smokers with chronic periodontitis. Thus, smoking is associated with specific structural alterations to the lipid-A-derived 3-OH fatty acid profile in saliva that are consistent with an oral microflora of reduced inflammatory potential. These findings provide much-needed mechanistic insight into the established clinical conundrum of increased infection with periodontal pathogens but reduced clinical inflammation in smokers.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Larsson, LennartLund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mmb-lla
(författare)
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Biyikoglu, B.
(författare)
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Renaud, D. E.
(författare)
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Bagaitkar, J.
(författare)
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Scott, D. A.
(författare)
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Avdelningen för medicinsk mikrobiologiInstitutionen för laboratoriemedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Dental Research: SAGE Publications90:1, s. 47-520022-03451544-0591
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