Sökning: onr:"swepub:oai:lup.lub.lu.se:d56fb286-7c1a-4cc4-a92d-60ae2b2775bf" >
Selective neuroprot...
-
Xilouri, Maria
(författare)
Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
-
2011-11-10
-
Oxford University Press (OUP),2012
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:d56fb286-7c1a-4cc4-a92d-60ae2b2775bf
-
https://lup.lub.lu.se/record/2416084URI
-
https://doi.org/10.1093/hmg/ddr521DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
Genetic studies have implicated the neuronal ubiquitin C-terminal hydrolase (UCH) protein UCH-L1 in Parkinson's disease (PD) pathogenesis. Moreover, the function of UCH-L1 may be lost in the brains of PD and Alzheimer's disease patients. We have previously reported that the UCH-L1 polymorphic variant S18Y, potentially protective against PD in population studies, demonstrates specific antioxidant functions in cell culture. Albeit genetic, biochemical and neuropathological data support an association between UCH-L1, PD, synaptic degeneration and oxidative stress, the relationship between the dopaminergic system and UCH-L1 status remains obscure. In the current study, we have examined the dopaminergic system of mice lacking endogenous UCH-L1 protein (gracile axonal dystrophy mice). Our findings show that the lack of wild-type (WT) UCH-L1 does not influence to any significant degree the dopaminergic system at baseline or following injections of the neurotoxin methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Furthermore, using a novel intrastriatal adenoviral injection protocol, we have found that mouse nigral neurons retrogradely transduced with S18Y UCH-L1, but not the WT protein, are significantly protected against MPTP toxicity. Overall, these data provide evidence for an antioxidant and neuroprotective effect of the S18Y variant of UCH-L1, but not of the WT protein, in the dopaminergic system, and may have implications for the pathogenesis of PD or related neurodegenerative conditions, in which oxidative stress might play a role.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Kyratzi, Elli
(författare)
-
Pitychoutis, Pothitos M.
(författare)
-
Papadopoulou-Daifoti, Zoi
(författare)
-
Perier, Celine
(författare)
-
Vila, Miquel
(författare)
-
Maniati, Matina
(författare)
-
Ulusoy, AyseLund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)mphy-aul
(författare)
-
Kirik, DenizLund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)mphy-dki
(författare)
-
Park, David S.
(författare)
-
Wada, Keiji
(författare)
-
Stefanis, Leonidas
(författare)
-
Brain Repair and Imaging in Neural Systems (BRAINS)Forskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Human Molecular Genetics: Oxford University Press (OUP)21:4, s. 874-8890964-69061460-2083
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Xilouri, Maria
-
Kyratzi, Elli
-
Pitychoutis, Pot ...
-
Papadopoulou-Dai ...
-
Perier, Celine
-
Vila, Miquel
-
visa fler...
-
Maniati, Matina
-
Ulusoy, Ayse
-
Kirik, Deniz
-
Park, David S.
-
Wada, Keiji
-
Stefanis, Leonid ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Medicinsk geneti ...
- Artiklar i publikationen
-
Human Molecular ...
- Av lärosätet
-
Lunds universitet