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Effect of different...
Effect of different asthma treatments on risk of cold-related exacerbations
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Reddel, H. K. (författare)
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Jenkins, C. (författare)
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Quirce, S. (författare)
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Sears, M. R. (författare)
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Bateman, E. D. (författare)
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O'Byrne, P. M. (författare)
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Humbert, M. (författare)
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Buhl, R. (författare)
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Harrison, T. (författare)
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Brusselle, G. G. (författare)
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Thoren, A. (författare)
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Sjobring, U. (författare)
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Peterson, S. (författare)
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Ostlund, O. (författare)
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- Eriksson, Göran (författare)
- Lund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 2011-03-15
- 2011
- Engelska.
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Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 38:3, s. 584-593
- Relaterad länk:
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http://dx.doi.org/10...
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https://erj.ersjourn...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Common colds often trigger asthma exacerbations. The present study compared cold-related severe exacerbations during budesonide/formoterol maintenance and reliever therapy, and different regimens of maintenance inhaled corticosteroids (ICS), with or without long-acting beta(2)-agonists (LABA), and with as-needed short-acting beta(2)-agonists (SABA) or LABA. Reported colds and severe exacerbations (defined by oral corticosteroid use and/or hospitalisation/emergency room visit) were assessed for 12,507 patients during 6-12 months of double-blind treatment. Exacerbations occurring <= 14 days after onset of reported colds were analysed by a Poisson model. The incidence of colds was similar across treatments. Asthma symptoms and reliever use increased during colds. Budesonide/formoterol maintenance and reliever therapy reduced severe cold-related exacerbations by 36% versus pooled comparators plus SABA (rate ratio (RR) 0.64; p=0.002), and for individual treatment comparisons, by 52% versus the same maintenance dose of ICS/LABA (RR 0.48; p < 0.001); there were nonsignificant reductions versus higher maintenance doses of ICS or ICS/LABA (RR 0.83 and 0.72, respectively). As-needed LABA did not reduce cold-related exacerbations versus as-needed SABA (RR 0.96). Severe cold-related exacerbations were reduced by budesonide/formoterol maintenance and reliever therapy compared with ICS with or without LABA and with as-needed SABA. Subanalyses suggested the importance of the ICS component in reducing cold-related exacerbations. Future studies should document the cause of exacerbations, in order to allow identification of different treatment effects.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Asthma
- drug therapy
- exacerbations
- respiratory tract infections
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Reddel, H. K.
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Jenkins, C.
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Quirce, S.
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Sears, M. R.
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Bateman, E. D.
-
O'Byrne, P. M.
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visa fler...
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Humbert, M.
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Buhl, R.
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Harrison, T.
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Brusselle, G. G.
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Thoren, A.
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Sjobring, U.
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Peterson, S.
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Ostlund, O.
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Eriksson, Göran
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visa färre...
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Lunds universitet