Sökning: onr:"swepub:oai:lup.lub.lu.se:d7337444-f136-4736-b526-5879f9b50248" > Risk of subsequent ...
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000 | 04968naa a2200457 4500 | |
001 | oai:lup.lub.lu.se:d7337444-f136-4736-b526-5879f9b50248 | |
003 | SwePub | |
008 | 190704s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/d7337444-f136-4736-b526-5879f9b502482 URI |
024 | 7 | a https://doi.org/10.1016/j.ejca.2019.05.0132 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Allodji, Rodrigue S.u University of Paris-Saclay,University of Birmingham,University of Abomey Calavi (UAC)4 aut |
245 | 1 0 | a Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup |
264 | 1 | b Elsevier BV,c 2019 |
300 | a 13 s. | |
520 | a Background: Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors. Methods: This largest-ever assembled cohort comprises 69,460 five-year childhood cancer survivors from 12 European countries. Standardised incidence ratios (SIRs) and absolute excess risks (AERs) were calculated. Results: One hundred fifteen survivors developed an SPL including 86 myeloid leukaemias (subsequent primary myeloid leukaemias [SPMLs]), 17 lymphoid leukaemias and 12 other types of leukaemias; of these SPLs, 31 (27%) occurred beyond 20 years from the first childhood cancer diagnosis. Compared with the general population, childhood cancer survivors had a fourfold increased risk (SIR = 3.7, 95% confidence interval [CI]: 3.1 to 4.5) of developing leukaemia, and eight leukaemias per 100,000 person-years (AER = 7.5, 95% CI: 6.0 to 9.2) occurred in excess of that expected. The risks remained significantly elevated beyond 20 years from the first primary malignancy (SIR = 2.4, 95% CI: 1.6 to 3.4). Overall, the risk ratio for SPML (SIR = 5.8, 95% CI: 4.6 to 7.1) was higher than that for other SPLs. Conclusions: We demonstrate that beyond 20 years after childhood cancer diagnosis, survivors experience an increased risk for SPLs compared with that expected from the general population. Our findings highlight the need for awareness by survivors and their healthcare providers for potential risk related to SPL. © 2019 Elsevier Ltd | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a Childhood cancer survivors | |
653 | a Lymphoid leukaemias | |
653 | a Myeloid leukaemias | |
653 | a Second cancers | |
653 | a Subsequent primary leukaemia | |
700 | 1 | a Garwicz, Stanislawu Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)st6750ga |
700 | 1 | a Linge, Helenau Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)medk-hjo |
700 | 1 | a Wiebe, Thomasu Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)pedi-twi |
700 | 1 | a Hjorth, Larsu Lund University,Lunds universitet,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,Late effects after childhood cancer treatment,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)pedi-lhj |
700 | 1 | a Reulen, Raoul C.u University of Birmingham4 aut |
710 | 2 | a University of Paris-Saclayb University of Birmingham4 org |
710 | 2 | a et al. |
773 | 0 | t European Journal of Cancerd : Elsevier BVg 117, s. 71-83q 117<71-83x 1879-0852x 0959-8049 |
856 | 4 | u http://dx.doi.org/10.1016/j.ejca.2019.05.013y FULLTEXT |
856 | 4 | u https://boris.unibe.ch/131818/8/Allodji%20EurJCancer%202019_postprint.pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/d7337444-f136-4736-b526-5879f9b50248 |
856 | 4 8 | u https://doi.org/10.1016/j.ejca.2019.05.013 |
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