Sökning: onr:"swepub:oai:lup.lub.lu.se:d78859c5-337d-4c8a-a88d-164515ca0c94" > Serological markers...
Fältnamn | Indikatorer | Metadata |
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000 | 03906naa a2200505 4500 | |
001 | oai:lup.lub.lu.se:d78859c5-337d-4c8a-a88d-164515ca0c94 | |
003 | SwePub | |
008 | 160401s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/37482962 URI |
024 | 7 | a https://doi.org/10.1136/gutjnl-2012-3027172 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a van Schaik, Fiona D. M.4 aut |
245 | 1 0 | a Serological markers predict inflammatory bowel disease years before the diagnosis |
264 | c 2012-07-26 | |
264 | 1 | b BMJ,c 2013 |
520 | a Objective Anti-neutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae mannan antibodies (ASCAs) have been detected in the serum of patients with ulcerative colitis (UC) and Crohn's disease (CD) and their unaffected family members. The aim of this study was to establish the value of serological markers as predictors of UC and CD. Design Individuals who developed CD or UC were identified from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. At recruitment, none of the participants had a diagnosis of CD or UC. For each incident case, two controls were randomly selected matched for centre, date of birth, sex, date of recruitment and time of follow-up. Serum of cases and controls obtained at recruitment were analysed for ASCA IgG, ASCA IgA, perinuclear anti-neutrophil cytoplasmic antibody (pANCA), antibodies against Escherichia coli outer membrane porin C (OmpC) and flagellin CBir1. Conditional logistic regression was used to determine risk of CD and UC. Receiver operating characteristic curves were constructed to test accuracy. Results A total of 77 individuals were diagnosed with CD and 167 with UC after a mean follow-up of 4.5 (SD 3.2) and 4.4 (SD 3.1) years following blood collection, respectively. Combinations of pANCA, ASCA, anti-CBir1 and anti-OmpC were most accurate in predicting incident CD and UC (area under curve 0.679 and 0.657, respectively). The predictive value of the combination of markers increased when time to diagnosis of CD or UC decreased. Conclusion A panel of serological markers is able to predict development of CD and UC in individuals from a low-risk population. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
700 | 1 | a Oldenburg, Bas4 aut |
700 | 1 | a Hart, Andrew R.4 aut |
700 | 1 | a Siersema, Peter D.4 aut |
700 | 1 | a Lindgren, Stefanu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups4 aut0 (Swepub:lu)medf-sli |
700 | 1 | a Grip, Olofu Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups4 aut0 (Swepub:lu)medf-ogr |
700 | 1 | a Teucher, Birgit4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Bergmann, Manuela M.4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Carbonnel, Franck4 aut |
700 | 1 | a Jantchou, Prevost4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christine4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Olsen, Anja4 aut |
700 | 1 | a Crowe, Francesca L.4 aut |
700 | 1 | a Peeters, Petra H. M.4 aut |
700 | 1 | a van Oijen, Martijn G. H.4 aut |
700 | 1 | a Bueno-de-Mesquita, H. Bas4 aut |
710 | 2 | a Gastroenterologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Gutd : BMJg 62:5, s. 683-688q 62:5<683-688x 1468-3288x 0017-5749 |
856 | 4 | u http://dx.doi.org/10.1136/gutjnl-2012-302717y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/3748296 |
856 | 4 8 | u https://doi.org/10.1136/gutjnl-2012-302717 |
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