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Pulmonary involveme...
Pulmonary involvement in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis : The influence of ANCA subtype
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- Mohammad, Aladdin J. (författare)
- Lund University,Lunds universitet,Lund Vasculitis Epidemiology Research Group,Forskargrupper vid Lunds universitet,Lund University Research Groups,Addenbrooke's Hospital
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- Mortensen, Kristian H. (författare)
- Addenbrooke's Hospital
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- Babar, Judith (författare)
- Addenbrooke's Hospital
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- Smith, Rona (författare)
- Addenbrooke's Hospital
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Jones, Rachel B (författare)
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- Nakagomi, Daiki (författare)
- Addenbrooke's Hospital
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- Sivasothy, Pasupathy (författare)
- Addenbrooke's Hospital
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- Jayne, David R. W. (författare)
- Addenbrooke's Hospital
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(creator_code:org_t)
- 2017-08-01
- 2017
- Engelska 10 s.
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Ingår i: Journal of Rheumatology. - : The Journal of Rheumatology. - 0315-162X .- 1499-2752. ; 44:10, s. 1458-1467
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Objective. To describe pulmonary involvement at time of diagnos is in a ntineutrophil cytoplasm ic antibodies (ANCA)-associated vasculitis (AAV), as defined by computed tomography (CT). Methods. Pati ents w ith thoracic CT perfor med on or after the onset of AAV (n = 140; 7 5 women; granulomatosis with polyangiitis, n = 79; microscopic polyangiitis MPA, n = 61) followed at a tertiary referral center vasculitis clinic were studied. Radiological patterns of pulmonary involvement were evaluated from the CT studies using a predefined protocol, and compared to proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA specificity. Results. Of the patients, 77% had an abnormal thoracic CT study. The most common abnormality was nodular disease (24%), of which the majority were peribronchial nodules, followed by bronchiectasis and pleural effusion (19%, each), pulmonary hemorrhage and lymph node enlargement (14%, each), emphysema (13%), and cavitating lesions (11%). Central airways disease and a n odular pattern of pulmonary involvement were more common in PR3-ANCA-positive patients (p < 0.05). Usual interstitial pneumonitis (UIP) and bronchiectasis were more prevalent in MPO-ANCA-positive patients (p < 0.05). Alveolar hemorrhage, pleural effusion, lymph node enlargement, and pulmonary venous congestion were more frequent in MPO-ANCA-positive patients. Conclusion. Pulmonary involvement is frequent and among 140 patients with AAV who underwent a thoracic CT study, almost 80% have pulmonary abnormalities on thoracic CT. Central airway disease oc curs exclusively among patients with PR3-ANCA while UIP were mainl y seen in those wit h MPO-ANCA. These findings may have important implications for the investigation, ma nagement, and pathogenesis of AAV.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- ANCA-Associated vasculitis
- Computed tomography scan
- Myeloperoxidase pulmonary
- Outcome
- Proteinase 3
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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