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Association between...
Association between time interval from neoadjuvant chemoradiotherapy to surgery and complete histological tumor response in esophageal and gastroesophageal junction cancer : a national cohort study
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- Klevebro, F. (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Nilsson, K. (författare)
- Karolinska University Hospital,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Esophageal & Gastr Canc Unit, Stockholm, Sweden.
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- Lindblad, M. (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Ekman, S. (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Johansson, J. (författare)
- Uppsala University,Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Upper Gastrointestinal Surgery,Forskargrupper vid Lunds universitet,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Surg, Lund, Sweden.
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- Lundell, L. (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Ndegwa, N. (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Esophageal & Gastr Canc Unit, Stockholm, Sweden.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Hedberg, Jakob, 1972- (författare)
- Uppsala universitet,Uppsala University,Gastrointestinalkirurgi
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- Nilsson, M. (författare)
- Karolinska Institutet,Karolinska University Hospital
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(creator_code:org_t)
- 2019-11-02
- 2020
- Engelska.
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Ingår i: Diseases of the Esophagus. - : Oxford University Press (OUP). - 1120-8694 .- 1442-2050. ; 33:5
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Abstract
Ämnesord
Stäng
- The optimal time interval from neoadjuvant therapy to surgery in the treatment of esophageal cancer is not known. The aim of this study was to investigate if a prolonged interval between completed neoadjuvant chemoradiotherapy and surgery was associated with improved histological response rates and survival in a population-based national register cohort. The population-based cohort study included patients treated with neoadjuvant chemoradiotherapy and esophagectomy due to cancer in the esophagus or gastroesophageal junction. Patients were divided into two groups based on the median time from completed neoadjuvant treatment to surgery. The primary outcome was complete histological response. Secondary outcomes were lymph node tumor response, postoperative complications, R0 resection rate, 90-day mortality, and overall survival. In total, 643 patients were included, 344 (54%) patients underwent surgery within 49 days, and 299 (47%) after 50 days or longer. The groups were similar concerning baseline characteristics except for a higher clinical tumor stage (P = 0.009) in the prolonged time to surgery group. There were no significant differences in complete histological response, R0 resection rate, postoperative complications, 90-day mortality, or overall survival. Adjusted odds ratio for ypT0 in the prolonged time to surgery group was 0.99 (95% confidence interval: 0.64-1.53). Complete histological response in the primary tumor (ypT0) was associated with significantly higher overall survival: adjusted hazard ratio: 0.55 (95% CI 0.41-0.76). If lymph node metastases were present in these patients, the survival was, however, significantly lower: adjusted hazard ratio for ypT0N1: 2.30 (95% CI 1.21-4.35). In this prospectively collected, nationwide cohort study of esophageal and junctional type 1 and 2 cancer patients, there were no associations between time to surgery and histological complete response, postoperative outcomes, or overall survival. The results suggest that it is safe for patients to postpone surgery at least 7 to 10 weeks after completed chemoradiotherapy, but no evidence was seen in favor of recommending a prolonged time to surgery after neoadjuvant chemoradiotherapy for esophageal cancer. A definitive answer to this question requires a randomized controlled trial of standard vs. prolonged time to surgery.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Chemoradiotherapy
- Cohort Studies
- Esophageal Neoplasms/pathology
- Esophagectomy
- Esophagogastric Junction/pathology
- Female
- Humans
- Male
- Neoadjuvant Therapy
- Neoplasm Staging
- Positron Emission Tomography Computed Tomography
- Treatment Outcome
- esophageal cancer
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Klevebro, F.
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Nilsson, K.
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Lindblad, M.
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Ekman, S.
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Johansson, J.
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Lundell, L.
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Ndegwa, N.
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Hedberg, Jakob, ...
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Nilsson, M.
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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Diseases of the ...
- Av lärosätet
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Lunds universitet
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Uppsala universitet
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Karolinska Institutet