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Association of age,...
Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort
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- Anand-Ivell, Ravinder (författare)
- University of Nottingham
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- Heng, Kee (författare)
- University of Nottingham
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- Severn, Katie (författare)
- University of Nottingham
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- Antonio, Leen (författare)
- Catholic University of Leuven,University Hospitals Leuven
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- Bartfai, Gyorgy (författare)
- University of Szeged
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- Casanueva, Felipe F. (författare)
- Complejo Hospitalario Universitario de Santiago
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- Huhtaniemi, Ilpo T. (författare)
- Imperial College London
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- Giwercman, Aleksander (författare)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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- Maggi, Mario (författare)
- University of Florence
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- O'Neill, Terence W. (författare)
- Centre for Epidemiology Versus Arthritis
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- Punab, Margus (författare)
- Tartu University Hospital
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- Rastrelli, Giulia (författare)
- University of Florence
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- Slowikowska-Hilczer, Jolanta (författare)
- Medical University of Lodz
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- Tournoy, Jos (författare)
- University Hospitals Leuven
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- Vanderschueren, Dirk (författare)
- Catholic University of Leuven,University Hospitals Leuven
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- Wu, Frederick C.W. (författare)
- Manchester University NHS Foundation Trust
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- Ivell, Richard (författare)
- University of Nottingham
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(creator_code:org_t)
- 2022-07-11
- 2022
- Engelska.
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Ingår i: Andrology. - : Wiley. - 2047-2919 .- 2047-2927. ; 10:7, s. 1328-1338
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Aging in men is accompanied by a broad range of symptoms, including sexual dysfunction, cognitive and musculoskeletal decline, obesity, type 2 diabetes, cardiovascular disease and hypertension, organ degeneration/failure, and increasing neoplasia, some of which are associated with declining levels of Leydig cell-produced testosterone. High natural biological variance, together with multiple factors that can modulate circulating testosterone concentration, may influence its interpretation and clinical implications. Insulin-like peptide 3 is a biomarker of Leydig cell function that might provide complementary information on testicular health and its downstream outcomes. Objectives: To characterize insulin-like peptide 3 as a biomarker to assess gonadal status in aging men. Methods and materials: A large European multicenter (European Male Aging Study) cohort of community-dwelling men was analyzed to determine how insulin-like peptide 3 relates to a range of hormonal, anthropometric, and lifestyle parameters. Results and discussion: Insulin-like peptide 3 declines cross-sectionally and longitudinally within individuals at approximately 15% per decade from age 40 years, unlike testosterone (1.9% per decade), which is partly compensated by increasing pituitary luteinizing hormone production. Importantly, lower insulin-like peptide 3 in younger men appears to persist with aging. Multiple regression analysis shows that, unlike testosterone, insulin-like peptide 3 is negatively dependent on luteinizing hormone and sex hormone-binding globulin and positively dependent on follicle-stimulating hormone, suggesting a different mechanism of gonadotropic regulation. Circulating insulin-like peptide 3 is negatively associated with increased body mass index or waist circumference and with smoking, and unlike testosterone, it is not affected by weight loss in obese individuals. Geographic variation in mean insulin-like peptide 3 within Europe appears to be largely explained by differences in these parameters. The results allowed the establishment of a European-wide reference range for insulin-like peptide 3 (95% confidence interval) adjusted for increasing age. Conclusion: Insulin-like peptide 3 is a constitutive biomarker of Leydig cell functional capacity and is a robust, reliably measurable peptide not subject to gonadotropin-dependent short-term regulation and within-individual variation in testosterone.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- aging male
- HPG axis
- hypogonadism
- INSL3
- Leydig cell
- testosterone
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Anand-Ivell, Rav ...
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Heng, Kee
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Severn, Katie
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Antonio, Leen
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Bartfai, Gyorgy
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Casanueva, Felip ...
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Huhtaniemi, Ilpo ...
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Giwercman, Aleks ...
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Maggi, Mario
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O'Neill, Terence ...
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Punab, Margus
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Rastrelli, Giuli ...
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Slowikowska-Hilc ...
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Tournoy, Jos
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Vanderschueren, ...
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Wu, Frederick C. ...
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Ivell, Richard
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Annan medicin oc ...
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och Gerontologi medi ...
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Andrology
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Lunds universitet