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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005252naa a2200361 4500
001oai:lup.lub.lu.se:d8ed4720-294c-4439-80aa-6c02957786cc
003SwePub
008160401s2009 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/14897882 URI
0247 a https://doi.org/10.1186/1471-2261-9-402 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Dimitrijevic, Ivanu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)expp-idi
2451 0a Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease
264 c 2009-08-25
264 1b Springer Science and Business Media LLC,c 2009
520 a Background: Endothelin-1 and angiotensin II are strong vasoconstrictors. Patients with ischemic heart disease have elevated plasma levels of endothelin-1 and angiotensin II and show increased vascular tone. The aim of the present study was to examine the endothelin and angiotensin II receptor expression in subcutaneous arteries from patients with different degrees of ischemic heart disease. Methods: Subcutaneous arteries were obtained, by biopsy from the abdomen, from patients undergoing coronary artery bypass graft (CABG) surgery because of ischemic heart disease (n = 15), patients with angina pectoris without established myocardial infarction (n = 15) and matched cardiovascular healthy controls (n = 15). Endothelin type A ( ETA) and type B (ETB), and angiotensin type 1 (AT(1)) and type 2 (AT(2)) receptors expression and function were examined using immunohistochemistry, Western blot and in vitro pharmacology. Results: ETA and, to a lesser extent, ETB receptor staining was observed in the healthy vascular smooth muscle cells. The level of ETB receptor expression was higher in patients undergoing CABG surgery (250% +/- 23%; P < 0.05) and in the patients with angina pectoris (199% +/- 6%; P < 0.05), than in the healthy controls (100% +/- 28%). The data was confirmed by Western blotting. Arteries from CABG patients showed increased vasoconstriction upon administration of the selective ETB receptor agonist sarafotoxin S6c, compared to healthy controls (P < 0.05). No such difference was found for the ETA receptors. AT(1) and, to a lesser extent, AT(2) receptor immunostaining was seen in the vascular smooth muscle cells. The level of AT(1) receptor expression was higher in both the angina pectoris (128% +/- 25%; P < 0.05) and in the CABG patients (203% +/- 41%; P < 0.05), as compared to the healthy controls (100% +/- 25%). The increased AT(1) receptor expression was confirmed by Western blotting. Myograph experiment did however not show any change in vasoconstriction to angiotensin II in CABG patients compared to healthy controls (P = n.s). Conclusion: The results demonstrate, for the first time, upregulation of ETB and AT(1) receptors in vascular smooth muscle cells in ischemic heart disease. These receptors may play a role in the pathophysiology of ischemic heart disease and could provide important targets for pharmaceutical interventions.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Edvinsson, Marie-Louise4 aut
7001 a Chen, Qingwenu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-qnc
7001 a Malmsjö, Malinu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Oftalmologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Ophthalmology, Lund,Section IV,Department of Clinical Sciences, Lund4 aut0 (Swepub:lu)med-mma
7001 a Kimblad, Per Olau Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)thor-pki
7001 a Edvinsson, Larsu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-led
7102 a Medicin, Lundb Sektion II4 org
7730 t BMC Cardiovascular Disordersd : Springer Science and Business Media LLCg 9q 9x 1471-2261
8564 u http://dx.doi.org/10.1186/1471-2261-9-40y FULLTEXT
8564 u https://bmccardiovascdisord.biomedcentral.com/track/pdf/10.1186/1471-2261-9-40
8564 8u https://lup.lub.lu.se/record/1489788
8564 8u https://doi.org/10.1186/1471-2261-9-40

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Dimitrijevic, Iv ...
Edvinsson, Marie ...
Chen, Qingwen
Malmsjö, Malin
Kimblad, Per Ola
Edvinsson, Lars
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MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
och Kardiologi
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BMC Cardiovascul ...
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Lunds universitet

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