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Labeling and testin...
Labeling and testing of (99m)Tc streptokinase for the diagnosis of deep vein thrombosis
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- Persson, B. R.R. (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Kempi, V. (författare)
- Lund University
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(creator_code:org_t)
- 1975
- 1975
- Engelska 4 s.
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Ingår i: Journal of Nuclear Medicine. - 0161-5505. ; 16:6, s. 474-477
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- A detailed study has been made of the method for labeling streptokinase with 99Tc(m) in order to get a radioactive indicator for rapid scintigraphic visualization of thrombi and emboli. The best method found for preparing 99Tc(m) streptokinase was by reducing 99Tc(m) pertechnetate with 2 μmole SnCl2 at pH 0.7 and then adding 50,000 to 75,000 IU of streptokinase at a final pH of about 2. After 1 hr of equilibration, the labeling efficiency was 75 to 80% as determined by the method of gel chromatography column scanning. The dynamic behavior and distribution of 99Tc(m) streptokinase in different organs was studied in rabbits where a high uptake was found in liver. In a clinical investigation using 99Tc(m) streptokinase prepared according to this work, however, the liver uptake in man was only 10 to 20%.
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