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Sökning: onr:"swepub:oai:lup.lub.lu.se:da046f46-3236-4527-9683-c3df609e5054" > Circulating pro-neu...

  • Barchetta, IlariaSapienza University of Rome (författare)

Circulating pro-neurotensin levels predict bodyweight gain and metabolic alterations in children

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2021

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:da046f46-3236-4527-9683-c3df609e5054
  • https://lup.lub.lu.se/record/da046f46-3236-4527-9683-c3df609e5054URI
  • https://doi.org/10.1016/j.numecd.2020.11.025DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background and aims: Neurotensin (NT) is an intestinal peptide released after fat ingestion, which regulates appetite and facilitates lipid absorption. Elevated plasma levels of its stable precursor pro-neurotensin (pro-NT) are associated with type 2 diabetes, obesity and cardiovascular mortality in adult populations; no data on pro-NT and metabolic disease are available in children. Aim of the study was to evaluate plasma pro-NT in relation to the presence of obesity in children, and to test if high pro-NT associates with the development of metabolic impairment later in life. Methods and results: For this longitudinal retrospective study, we studied 151 overweight/obese children undergoing metabolic evaluations at University of Cagliari, Italy. Pro-NT was also assessed in 46 normal-weight, age-, sex-comparable normal-weight children, selected as a reference group. At the baseline, pro-NT was comparable between overweight/obese and normal-weight children and correlated positively with age (p < 0.001), triglycerides (p < 0.001) and inversely with HDL levels (p = 0.008). Plasma pro-NT associated with high triglycerides with OR = 5.9 (95%CI: 1.24–28.1; p = 0.026) after adjustment for multiple confounders. At the 6.5-year follow-up, high basal pro-NT associated with impaired β-cell function to compensate for insulin-resistance (disposition index: r = −0.19, p = 0.035) and predicted bodyweight increase, as indicated by percentage change of standard deviation score BMI (median(95%CI) = +20.8(+4.9-+27.5)% in the highest tertile), independently from age, sex, triglycerides and insulin-resistance (standardized β = 0.24; p = 0.036). Conclusions: Elevated pro-NT levels in children are significantly associated with weight gain later in life and may represent a marker of susceptibility to metabolic impairment in presence of obesity.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bertoccini, LauraSapienza University of Rome (författare)
  • Sentinelli, FedericaSapienza University of Rome,University of L'Aquila (författare)
  • Bailetti, DiegoSapienza University of Rome,University of L'Aquila (författare)
  • Marini, GiacomoUniversity of Cagliari (författare)
  • Cimini, Flavia AgataSapienza University of Rome (författare)
  • Ceccarelli, ValentinaSapienza University of Rome (författare)
  • Struck, JoachimSphingotec GmbH (författare)
  • Schulte, JaninSphingotec GmbH (författare)
  • Loche, SandroRegional Hospital For Microcitemia (författare)
  • Cossu, EfisioUniversity of Cagliari (författare)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-ome (författare)
  • Cavallo, Maria G.Sapienza University of Rome (författare)
  • Baroni, Marco G.University of L'Aquila,Istituto Neurologico Mediterraneo Neuromed (författare)
  • Sapienza University of RomeUniversity of L'Aquila (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nutrition, Metabolism and Cardiovascular Diseases: Elsevier BV31:3, s. 902-9100939-4753

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