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Dimethylguanidino v...
Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes
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- O’Sullivan, John F. (författare)
- University of Sydney,Massachusetts General Hospital
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- Morningstar, Jordan E. (författare)
- Harvard Medical School
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- Yang, Qiong (författare)
- National Heart Lung and Blood Institute,Boston University
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- Zheng, Baohui (författare)
- Harvard Medical School,Massachusetts General Hospital
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- Gao, Yan (författare)
- University of Mississippi Medical Center
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- Jeanfavre, Sarah (författare)
- Broad Institute
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- Scott, Justin (författare)
- Broad Institute
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- Fernandez, Celine (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Zheng, Hui (författare)
- Harvard Medical School,Massachusetts General Hospital
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- O’Connor, Sean (författare)
- Rockefeller University
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- Cohen, Paul (författare)
- Rockefeller University
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- Vasan, Ramachandran S. (författare)
- National Heart Lung and Blood Institute,Boston University
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- Long, Michelle T. (författare)
- Boston University
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- Wilson, James G. (författare)
- University of Mississippi Medical Center
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Wang, Thomas J. (författare)
- Vanderbilt University
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- Fox, Caroline (författare)
- National Heart Lung and Blood Institute,Boston University
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- Peterson, Randall T. (författare)
- Harvard Medical School,Massachusetts General Hospital
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- Clish, Clary B. (författare)
- Broad Institute
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- Corey, Kathleen E. (författare)
- Massachusetts General Hospital
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- Gerszten, Robert E. (författare)
- Broad Institute,Harvard Medical School
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(creator_code:org_t)
- 2017
- 2017
- Engelska 9 s.
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Ingår i: Journal of Clinical Investigation. - 0021-9738. ; 127:12, s. 4394-4402
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Unbiased, “nontargeted” metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CT-defined nonalcoholic fatty liver disease (NAFLD) in the offspring cohort of the Framingham Heart Study (FHS) participants. We verified the relationship between DMGV and early hepatic pathology. Specifically, plasma DMGV levels were correlated with biopsy-proven nonalcoholic steatohepatitis (NASH) in a hospital cohort of individuals undergoing gastric bypass surgery, and DMGV levels fell in parallel with improvements in post-procedure cardiometabolic parameters. Further, baseline DMGV levels independently predicted future diabetes up to 12 years before disease onset in 3 distinct human cohorts. Finally, we provide all metabolite peak data consisting of known and unidentified peaks, genetics, and key metabolic parameters as a publicly available resource for investigations in cardiometabolic diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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O’Sullivan, John ...
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Morningstar, Jor ...
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Yang, Qiong
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Zheng, Baohui
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Gao, Yan
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Jeanfavre, Sarah
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visa fler...
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Scott, Justin
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Fernandez, Celin ...
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Zheng, Hui
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O’Connor, Sean
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Cohen, Paul
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Vasan, Ramachand ...
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Long, Michelle T ...
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Wilson, James G.
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Melander, Olle
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Wang, Thomas J.
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Fox, Caroline
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Peterson, Randal ...
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Clish, Clary B.
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Corey, Kathleen ...
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Gerszten, Robert ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Lunds universitet