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Crosstalk between t...
Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation
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- Bekassy, Zivile (författare)
- Lund University,Lunds universitet,Pediatrisk nefrologi,Forskargrupper vid Lunds universitet,Pediatric Nephrology,Lund University Research Groups
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- Lopatko Fagerström, Ingrid (författare)
- Lund University,Lunds universitet,Pediatrisk nefrologi,Forskargrupper vid Lunds universitet,Pediatric Nephrology,Lund University Research Groups
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- Bader, Michael (författare)
- Max Delbrück Center for Molecular Medicine (MDC),German Centre for Cardiovascular Research,Charité - University Medicine Berlin
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- Karpman, Diana (författare)
- Lund University,Lunds universitet,Pediatrisk nefrologi,Forskargrupper vid Lunds universitet,Pediatric Nephrology,Lund University Research Groups
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(creator_code:org_t)
- 2021-11-10
- 2022
- Engelska.
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Ingår i: Nature Reviews Immunology. - : Springer Science and Business Media LLC. - 1474-1733 .- 1474-1741. ; 22:7, s. 411-428
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin–angiotensin system, the complement system, and the closely linked kallikrein–kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation. Specific attention is given to the role of these systems in systemic inflammation in the vasculature and tissues during hereditary angioedema, cardiovascular and renal glomerular disease, vasculitides and COVID-19. Moreover, we discuss the therapeutic implications of these complex interactions, given that modulation of one system may affect the other systems, with beneficial or deleterious consequences.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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