Sökning: onr:"swepub:oai:lup.lub.lu.se:dbfc380a-7a2b-47d6-a377-ab72d48faee3" > Perfluoroalkyl subs...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04834naa a2200445 4500 | |
001 | oai:lup.lub.lu.se:dbfc380a-7a2b-47d6-a377-ab72d48faee3 | |
003 | SwePub | |
008 | 190521s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/dbfc380a-7a2b-47d6-a377-ab72d48faee32 URI |
024 | 7 | a https://doi.org/10.1186/1476-069X-13-1162 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Jørgensen, Kristian T.u Bispebjerg Hospital4 aut |
245 | 1 0 | a Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
264 | 1 | c 2014 |
520 | a Background: Perfluoroalkyl substances (PFAS) are suggested to affect human fecundity through longer time to pregnancy (TTP). We studied the relationship between four abundant PFAS and TTP in pregnant women from Greenland, Poland and Ukraine representing varying PFAS exposures and pregnancy planning behaviors. Methods: We measured serum levels of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) in 938 women from Greenland (448 women), Poland (203 women) and Ukraine (287 women). PFAS exposure was assessed on a continuous logarithm transformed scale and in country-specific tertiles. We used Cox discrete-time models and logistic regression to estimate fecundability ratios (FRs) and infertility (TTP >13 months) odds ratios (ORs), respectively, and 95% confidence intervals (CI) according to PFAS levels. Adjusted analyses of the association between PFAS and TTP were done for each study population and in a pooled sample. Results: Higher PFNA levels were associated with longer TTP in the pooled sample (log-scale FR∈=∈0.80; 95% CI 0.69-0.94) and specifically in women from Greenland (log-scale FR∈=∈0.72; 95% CI 0.58-0.89). ORs for infertility were also increased in the pooled sample (log-scale OR∈=∈1.53; 95% CI 1.08-2.15) and in women from Greenland (log-scale OR∈=∈1.97; 95% CI 1.22-3.19). However, in a sensitivity analysis of primiparous women these associations could not be replicated. Associations with PFNA were weaker for women from Poland and Ukraine. PFOS, PFOA and PFHxS were not consistently associated with TTP. Conclusions: Findings do not provide consistent evidence that environmental exposure to PFAS is impairing female fecundity by delaying time taken to conceive. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
653 | a Fecundity | |
653 | a Infertility | |
653 | a Perfluorinated compounds | |
653 | a Persistent environmental pollutants | |
700 | 1 | a Specht, Ina O.u Bispebjerg Hospital4 aut |
700 | 1 | a Lenters, Virissau Utrecht University4 aut |
700 | 1 | a Bach, Cathrine C.u Aarhus University Hospital4 aut |
700 | 1 | a Rylander, Larsu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-lry |
700 | 1 | a Jönsson, Bo A.G.u Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-bjo |
700 | 1 | a Lindh, Christian H.u Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-cli |
700 | 1 | a Giwercman, Aleksanderu Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kir-agi |
700 | 1 | a Heederik, Dicku Utrecht University4 aut |
700 | 1 | a Toft, Gunnaru Aarhus University Hospital4 aut |
700 | 1 | a Bonde, Jens Peteru Bispebjerg Hospital4 aut |
710 | 2 | a Bispebjerg Hospitalb Utrecht University4 org |
773 | 0 | t Environmental Health: A Global Access Science Sourceg 13:1q 13:1x 1476-069X |
856 | 4 | u http://dx.doi.org/10.1186/1476-069X-13-116x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/dbfc380a-7a2b-47d6-a377-ab72d48faee3 |
856 | 4 8 | u https://doi.org/10.1186/1476-069X-13-116 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy