Sökning: onr:"swepub:oai:lup.lub.lu.se:dcc3c780-3c53-4b01-af0b-bb2b322ae07e" > Acute phase markers...
Fältnamn | Indikatorer | Metadata |
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000 | 04132naa a2200433 4500 | |
001 | oai:lup.lub.lu.se:dcc3c780-3c53-4b01-af0b-bb2b322ae07e | |
003 | SwePub | |
008 | 201021s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/dcc3c780-3c53-4b01-af0b-bb2b322ae07e2 URI |
024 | 7 | a https://doi.org/10.1016/j.pneurobio.2020.1019042 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Ayton, Scottu University of Melbourne4 aut |
245 | 1 0 | a Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE ε4, sex and age |
264 | 1 | b Elsevier BV,c 2021 |
520 | a It is unknown how neuroinflammation may feature in the etiology of Alzheimer's disease (AD). We profiled acute phase response (APR) proteins (α1-antitrypsin, α1-antichymotrypsin, ceruloplasmin, complement C3, ferritin, α-fibrinogen, β-fibrinogen, γ-fibrinogen, haptoglobin, hemopexin) in CSF of 1291 subjects along the clinical and biomarker spectrum of AD to investigate the association between inflammatory changes, disease outcomes, and demographic variables. Subjects were stratified by Aβ42/t-tau as well as the following clinical diagnoses: cognitively normal (CN); subjective cognitive decline (SCD); mild cognitive impairment (MCI); and AD dementia. In separate multiple regressions (adjusting for diagnosis, age, sex, APOE-ε4) of each APR protein and a composite of all APR proteins, CSF Aβ42/t-tau status was associated with elevated ferritin, but not any other APR protein in CN and SCD subjects. Rather, the APR was elevated along with symptomatic progression (CN < SCD < MCI < AD), and this was elevation was mediated by CSF p-tau181. APOE ε4 status did not affect levels of any APR proteins in CSF, while these were elevated in males and with increased age. The performance of the APR in predicting clinical diagnosis was influenced by APOE ε4 status, sex, and age. These data provide new insight into inflammatory changes in AD and how this intersects with pathology changes and patient demographics. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a acute phase response | |
653 | a Alzheimer's disease | |
653 | a biomarkers | |
653 | a Neuroinflammation | |
700 | 1 | a Janelidze, Shorenau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)nkir-sje |
700 | 1 | a Roberts, Blaineu University of Melbourne4 aut |
700 | 1 | a Palmqvist, Sebastianu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-spa |
700 | 1 | a Kalinowski, Pawelu University of Melbourne4 aut |
700 | 1 | a Diouf, Ibrahimau University of Melbourne4 aut |
700 | 1 | a Belaidi, Abdel A.u University of Melbourne4 aut |
700 | 1 | a Stomrud, Eriku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-esr |
700 | 1 | a Bush, Ashley I.u University of Melbourne4 aut |
700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn |
710 | 2 | a University of Melbourneb Klinisk minnesforskning4 org |
773 | 0 | t Progress in Neurobiologyd : Elsevier BVg 198q 198x 0301-0082 |
856 | 4 | u http://dx.doi.org/10.1016/j.pneurobio.2020.101904y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/dcc3c780-3c53-4b01-af0b-bb2b322ae07e |
856 | 4 8 | u https://doi.org/10.1016/j.pneurobio.2020.101904 |
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