Sökning: onr:"swepub:oai:lup.lub.lu.se:dd3c1cf3-397d-4d51-9756-a22b261e6272" >
Prognostic implicat...
Prognostic implications of BCL6 rearrangement in uniformly treated patients with diffuse large B-cell lymphoma--a Nordic Lymphoma Group study.
-
- Jerkeman, Mats (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Aman, P (författare)
-
- Cavallin-Ståhl, Eva (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
visa fler...
-
Torlakovic, E (författare)
-
- Åkerman, Måns (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Mitelman, Felix (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
-
- Fioretos, Thoas (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
-
visa färre...
-
(creator_code:org_t)
- 2002
- 2002
- Engelska.
-
Ingår i: International Journal of Oncology. - 1019-6439. ; 20:1, s. 161-165
- Relaterad länk:
-
http://www.ncbi.nlm.... (free)
-
visa fler...
-
http://147.52.72.117... (free)
-
https://lup.lub.lu.s...
-
visa färre...
Abstract
Ämnesord
Stäng
- The purpose of this study was to investigate the prognostic implications of BCL6 rearrangement in a uniformly treated population of patients with diffuse large B-cell lymphoma (DLBCL) and to characterise the relationship between BCL6 rearrangement and prognostic factors. A total of 269 patients with DLBCL entered a randomised trial comparing the chemotherapy regimen CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) to the MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin) regimen. In 44 cases, frozen tissue was available for assessment of BCL6 status by Southern blot analysis. BCL6 was rearranged in six of 43 evaluable cases (14%), and was associated with elevated lactate dehydrogenase (LDH), and a higher patient age. No association between BCL6 status and expression of BCL2, Ki-67 or TP53 was found. Patients presenting with BCL6 rearrangement displayed a weak trend towards better overall and failure-free survival (67 and 67% at 5 years), compared to patients with germline BCL6 (63 and 52%), but the difference was not statistically significant. In accordance with previously published series, the presence of BCL6 rearrangement does not define a prognostically distinct subgroup of DLBCL. Assessment of BCL6 status may, however, be of clinical interest when related to other prognostic variables.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Gene Rearrangement B-Lymphocyte : genetics
- Human
- Immunophenotyping
- Lymphoma B-Cell : drug therapy : genetics
- Leucovorin : therapeutic use
- Lactate Dehydrogenase : metabolism
- Lymphoma Large-Cell Diffuse : drug therapy : genetics
- Male
- Methotrexate : therapeutic use
- Middle Age
- Neoplasm Staging
- Prednisone : therapeutic use
- Prognosis
- Proto-Oncogene Proteins : genetics
- Support Non-U.S. Gov't
- Vincristine : therapeutic use
- Transcription Factors : genetics
- Doxorubicin : therapeutic use
- DNA-Binding Proteins : genetics
- DNA Neoplasm : analysis : metabolism
- Cyclophosphamide : therapeutic use
- Blotting Southern
- Bleomycin : therapeutic use
- Antineoplastic Combined Chemotherapy Protocols : therapeutic use
- Aged
- Adolescence
- Adult
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas