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Transcriptome analysis of avian livers reveals different molecular changes to three urban pollutants : Soot, artificial light at night and noise
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- Isaksson, C. (författare)
- Lund University,Lunds universitet,BECC: Biodiversity and Ecosystem services in a Changing Climate,Centrum för miljö- och klimatvetenskap (CEC),Naturvetenskapliga fakulteten,Ekologisk och evolutionär fysiologi,Forskargrupper vid Lunds universitet,LTH profilområde: Aerosoler,LTH profilområden,Lunds Tekniska Högskola,Evolutionär ekologi och infektionsbiologi,Avdelningar vid Biologiska institutionen,Biologiska institutionen,Centre for Environmental and Climate Science (CEC),Faculty of Science,Ecological and Evolutionary Physiology,Lund University Research Groups,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH,Evolutionary ecology and infection biology,Sections at the Department of Biology,Department of Biology
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- Ziegler, A. K. (författare)
- Lund University,Lunds universitet,Molekylär ekologi och evolution,Forskargrupper vid Lunds universitet,Evolutionär ekologi och infektionsbiologi,Avdelningar vid Biologiska institutionen,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Ecology and Evolution Lab,Lund University Research Groups,Evolutionary ecology and infection biology,Sections at the Department of Biology,Department of Biology,Faculty of Science
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- Powell, D. (författare)
- Lund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science
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- (creator_code:org_t)
- 2024
- 2024
- Engelska.
- Ingår i: Environmental Pollution. - 0269-7491. ; 358
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Identifying key molecular pathways and genes involved in the response to urban pollutants is an important step in furthering our understanding of the impact of urbanisation on wildlife. The expansion of urban habitats and the associated human-introduced environmental changes are considered a global threat to the health and persistence of humans and wildlife. The present study experimentally investigates how short-term exposure to three urban-related pollutants -soot, artificial light at night (ALAN) and traffic noise-affects transcriptome-wide gene expression in livers from captive female zebra finches (Taeniopygia guttata). Compared to unexposed controls, 17, 52, and 28 genes were differentially expressed in soot, ALAN and noise-exposed birds, respectively. In soot-exposed birds, the enriched gene ontology (GO) terms were associated with a suppressed immune system such as interferon regulating genes (IRGs) and responses to external stimuli. For ALAN-exposed birds, enriched GO terms were instead based on downregulated genes associated with detoxification, redox, hormonal-, and metabolic processes. Noise exposure resulted in downregulation of genes associated with the GO terms: cellular responses to substances, catabolic and cytokine responses. Among the individually differentially expressed genes (DEGs), soot led to an increased expression of genes related to tumour progression. Likewise, ALAN revealed an upregulation of multiple genes linked to different cancer types. Both sensory pollutants (ALAN and noise) led to increased expression of genes linked to neuronal function. Interestingly, noise caused upregulation of genes associated with serotonin regulation and function (SLC6A4 and HTR7), which previous studies have shown to be under selection in urban birds. These outcomes indicate that short-term exposure to the three urban pollutants perturbate the liver transcriptome, but most often in different ways, which highlights future studies of multiple-stress exposure and their interactive effects, along with their long-term impacts for urban-dwelling wildlife.
Ämnesord
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- ALAN
- Gene expression
- Particulate matter
- Sensory pollution
- Zebra finch
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- Isaksson, C.
- Ziegler, A. K.
- Powell, D.
- Gudmundsson, A.
- Andersson, M. N.
- Rissler, J.
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