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Galectin-3 released...
Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration
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- Yip, Ping Kei (författare)
- Queen Mary University
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- Carrillo-Jimenez, Alejandro (författare)
- University Hospital Virgen del Rocío,University of Seville
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- King, Paul (författare)
- Queen Mary University
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visa fler...
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- Vilalta, Anna (författare)
- University of Cambridge
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- Nomura, Koji (författare)
- University of Cambridge
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- Chau, Chi Cheng (författare)
- Queen Mary University
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- Egerton, Alexander Michael Scott (författare)
- Queen Mary University
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- Liu, Zhuo Hao (författare)
- Queen Mary University,Chang Gung University
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- Shetty, Ashray Jayaram (författare)
- Queen Mary University
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- Tremoleda, Jordi L. (författare)
- Queen Mary University
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- Davies, Meirion (författare)
- Queen Mary University
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- Deierborg, Tomas (författare)
- Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Priestley, John V. (författare)
- Queen Mary University
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- Brown, Guy Charles (författare)
- University of Cambridge
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- Michael-Titus, Adina Teodora (författare)
- Queen Mary University
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- Venero, Jose Luis (författare)
- University Hospital Virgen del Rocío,University of Seville
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- Burguillos, Miguel Angel (författare)
- Queen Mary University
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visa färre...
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(creator_code:org_t)
- 2017-01-27
- 2017
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
- Relaterad länk:
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http://dx.doi.org/10... (free)
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visa fler...
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Traumatic brain injury (TBI) is currently a major cause of morbidity and poor quality of life in Western society, with an estimate of 2.5 million people affected per year in Europe, indicating the need for advances in TBI treatment. Within the first 24 h after TBI, several inflammatory response factors become upregulated, including the lectin galectin-3. In this study, using a controlled cortical impact (CCI) model of head injury, we show a large increase in the expression of galectin-3 in microglia and also an increase in the released form of galectin-3 in the cerebrospinal fluid (CSF) 24 h after head injury. We report that galectin-3 can bind to TLR-4, and that administration of a neutralizing antibody against galectin-3 decreases the expression of IL-1β, IL-6, TNFα and NOS2 and promotes neuroprotection in the cortical and hippocampal cell populations after head injury. Long-term analysis demonstrated a significant neuroprotection in the cortical region in the galectin-3 knockout animals in response to TBI. These results suggest that following head trauma, released galectin-3 may act as an alarmin, binding, among other proteins, to TLR-4 and promoting inflammation and neuronal loss. Taking all together, galectin-3 emerges as a clinically relevant target for TBI therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Yip, Ping Kei
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Carrillo-Jimenez ...
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King, Paul
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Vilalta, Anna
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Nomura, Koji
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Chau, Chi Cheng
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visa fler...
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Egerton, Alexand ...
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Liu, Zhuo Hao
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Shetty, Ashray J ...
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Tremoleda, Jordi ...
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Davies, Meirion
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Deierborg, Tomas
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Priestley, John ...
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Brown, Guy Charl ...
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Michael-Titus, A ...
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Venero, Jose Lui ...
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Burguillos, Migu ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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Scientific Repor ...
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Lunds universitet