Sökning: onr:"swepub:oai:lup.lub.lu.se:dfa3d4ed-b291-4310-9120-30ed245f1905" > Variations in the G...
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000 | 04986naa a2200889 4500 | |
001 | oai:lup.lub.lu.se:dfa3d4ed-b291-4310-9120-30ed245f1905 | |
003 | SwePub | |
008 | 160404s2008 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/11692422 URI |
024 | 7 | a https://doi.org/10.1172/JCI345662 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Chen, Wei-Min4 aut |
245 | 1 0 | a Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. |
264 | 1 | c 2008 |
520 | a Identifying the genetic variants that regulate fasting glucose concentrations may further our understanding of the pathogenesis of diabetes. We therefore investigated the association of fasting glucose levels with SNPs in 2 genome-wide scans including a total of 5,088 nondiabetic individuals from Finland and Sardinia. We found a significant association between the SNP rs563694 and fasting glucose concentrations (P = 3.5 x 10(-7)). This association was further investigated in an additional 18,436 nondiabetic individuals of mixed European descent from 7 different studies. The combined P value for association in these follow-up samples was 6.9 x 10(-26), and combining results from all studies resulted in an overall P value for association of 6.4 x 10(-33). Across these studies, fasting glucose concentrations increased 0.01-0.16 mM with each copy of the major allele, accounting for approximately 1% of the total variation in fasting glucose. The rs563694 SNP is located between the genes glucose-6-phosphatase catalytic subunit 2 (G6PC2) and ATP-binding cassette, subfamily B (MDR/TAP), member 11 (ABCB11). Our results in combination with data reported in the literature suggest that G6PC2, a glucose-6-phosphatase almost exclusively expressed in pancreatic islet cells, may underlie variation in fasting glucose, though it is possible that ABCB11, which is expressed primarily in liver, may also contribute to such variation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Erdos, Michael R4 aut |
700 | 1 | a Jackson, Anne U4 aut |
700 | 1 | a Saxena, Richa4 aut |
700 | 1 | a Sanna, Serena4 aut |
700 | 1 | a Silver, Kristi D4 aut |
700 | 1 | a Timpson, Nicholas J4 aut |
700 | 1 | a Hansen, Torben4 aut |
700 | 1 | a Orrù, Marco4 aut |
700 | 1 | a Grazia Piras, Maria4 aut |
700 | 1 | a Bonnycastle, Lori L4 aut |
700 | 1 | a Willer, Cristen J4 aut |
700 | 1 | a Lyssenko, Valeriyau Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly |
700 | 1 | a Shen, Haiqing4 aut |
700 | 1 | a Kuusisto, Johanna4 aut |
700 | 1 | a Ebrahim, Shah4 aut |
700 | 1 | a Sestu, Natascia4 aut |
700 | 1 | a Duren, William L4 aut |
700 | 1 | a Spada, Maria Cristina4 aut |
700 | 1 | a Stringham, Heather M4 aut |
700 | 1 | a Scott, Laura J4 aut |
700 | 1 | a Olla, Nazario4 aut |
700 | 1 | a Swift, Amy J4 aut |
700 | 1 | a Najjar, Samer4 aut |
700 | 1 | a Mitchell, Braxton D4 aut |
700 | 1 | a Lawlor, Debbie A4 aut |
700 | 1 | a Smith, George Davey4 aut |
700 | 1 | a Ben-Shlomo, Yoav4 aut |
700 | 1 | a Andersen, Gitte4 aut |
700 | 1 | a Borch-Johnsen, Knut4 aut |
700 | 1 | a Jørgensen, Torben4 aut |
700 | 1 | a Saramies, Jouko4 aut |
700 | 1 | a Valle, Timo T4 aut |
700 | 1 | a Buchanan, Thomas A4 aut |
700 | 1 | a Shuldiner, Alan R4 aut |
700 | 1 | a Lakatta, Edward4 aut |
700 | 1 | a Bergman, Richard N4 aut |
700 | 1 | a Uda, Manuela4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a Pedersen, Oluf4 aut |
700 | 1 | a Cao, Antonio4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Mohlke, Karen L4 aut |
700 | 1 | a Laakso, Markku4 aut |
700 | 1 | a Schlessinger, David4 aut |
700 | 1 | a Collins, Francis S4 aut |
700 | 1 | a Altshuler, David4 aut |
700 | 1 | a Abecasis, Gonçalo R4 aut |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a Scuteri, Angelo4 aut |
700 | 1 | a Watanabe, Richard M4 aut |
710 | 2 | a Translationell Muskel Forskningb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Journal of Clinical Investigationg Jun 2, s. 2620-2628q Jun 2<2620-2628x 0021-9738 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/18521185?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1172/JCI34566y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/1169242 |
856 | 4 8 | u https://doi.org/10.1172/JCI34566 |
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