onr:"swepub:oai:lup.lub.lu.se:dfd9e5d1-0f4e-45ae-acfb-1aec307ed336"
Sökning: onr:"swepub:oai:lup.lub.lu.se:dfd9e5d1-0f4e-45ae-acfb-1aec307ed336" > Distinct somatic ge...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04949naa a2200613 4500 | |
| 001 | oai:lup.lub.lu.se:dfd9e5d1-0f4e-45ae-acfb-1aec307ed336 | |
| 003 | SwePub | |
| 008 | 160918s1997 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/dfd9e5d1-0f4e-45ae-acfb-1aec307ed3362 URI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Tirkkonen, M4 aut |
| 245 | 1 0 | a Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations |
| 264 | 1 | c 1997 |
| 300 | a 6 s. | |
| 520 | a BRCA1 and BRCA2 mutations confer increased risk for development of breast cancer, but a number of additional, currently largely unknown, somatic genetic defects must also accumulate in the breast epithelial cells before malignancy develops. To evaluate the nature of these additional somatic genetic defects, we performed a genome-wide survey by comparative genomic hybridization on breast cancers from 21 BRCA1 mutation carriers, 15 BRCA2 mutation carriers, and 55 unselected controls. The total number of genetic changes was almost two times higher in tumors from both BRCA1 and BRCA2 mutation carriers than in the control group. In BRCA1 tumors, losses of 5q (86%), 4q (81%), 4p (64%), 2q (40%), and 12q (40%) were significantly more common than in the control group (7-13%). BRCA2 tumors were characterized by a higher frequency of 13q (73%) and 6q (60%) losses and gains of 17q22-q24 (87%) and 20q13 (60%) as compared to the prevalence of these changes in the control group (12-18%). In conclusion, accumulation of somatic genetic changes during tumor progression may follow a unique pathway in individuals genetically predisposed to cancer, especially by the BRCA1 gene. Activation or loss of genes in the affected chromosomal regions may be selected for during tumor progression in cells lacking functional BRCA1 or BRCA2. Identification of such genes could provide targets for therapeutic intervention and early diagnosis. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a Adult | |
| 653 | a Aged | |
| 653 | a Aged, 80 and over | |
| 653 | a BRCA2 Protein | |
| 653 | a Breast Neoplasms | |
| 653 | a Carcinoma, Ductal, Breast | |
| 653 | a Chromosome Deletion | |
| 653 | a Chromosomes, Human, Pair 4 | |
| 653 | a Chromosomes, Human, Pair 5 | |
| 653 | a Disease Progression | |
| 653 | a Female | |
| 653 | a Genes, BRCA1 | |
| 653 | a Germ-Line Mutation | |
| 653 | a Heterozygote | |
| 653 | a Humans | |
| 653 | a Middle Aged | |
| 653 | a Neoplasm Proteins | |
| 653 | a Nucleic Acid Hybridization | |
| 653 | a Polymorphism, Single-Stranded Conformational | |
| 653 | a Transcription Factors | |
| 700 | 1 | a Johannsson, Ou Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)extLU-1462 |
| 700 | 1 | a Agnarsson, B A4 aut |
| 700 | 1 | a Olsson, Håkanu Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumörmikromiljö,Institutionen för kliniska vetenskaper, Lund,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Tumor microenvironment,Department of Clinical Sciences, Lund,Lund Melanoma Study Group,Lund University Research Groups4 aut0 (Swepub:lu)onk-hol |
| 700 | 1 | a Ingvarsson, Su Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)immu-sin |
| 700 | 1 | a Karhu, R4 aut |
| 700 | 1 | a Tanner, M4 aut |
| 700 | 1 | a Isola, Ju Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-jis |
| 700 | 1 | a Barkardottir, R B4 aut |
| 700 | 1 | a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo |
| 700 | 1 | a Kallioniemi, O P4 aut |
| 710 | 2 | a Bröstcancer-genetikb Sektion I4 org |
| 773 | 0 | t Cancer Researchg 57:7, s. 7-1222q 57:7<7-1222x 0008-5472 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/dfd9e5d1-0f4e-45ae-acfb-1aec307ed336 |
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