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The Benefits and Ha...
The Benefits and Harms of Pharmacological Treatment for Postradiation Pelvic Pain : A Systematic Review by the European Association of Urology Chronic Pelvic Pain Panel with Recommendations for Clinical Practice
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- Zumstein, Valentin (författare)
- University of St. Gallen
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- Parsons, Brian A. (författare)
- Royal Devon & Exeter Hospital
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- Dabestani, Saeed (författare)
- Lund University,Lunds universitet,Urologi,Forskargrupper vid Lunds universitet,Urology,Lund University Research Groups,Central Hospital Kristianstad
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- Baranowski, Andrew P. (författare)
- National Hospital for Neurology and Neurosurgery
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- Tidman, Victoria (författare)
- National Hospital for Neurology and Neurosurgery
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- Berghmans, Bary (författare)
- Maastricht University
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- Borovicka, Jan (författare)
- University of St. Gallen
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- Cottrell, Angela M. (författare)
- East of England Deanery
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- Dinis-Oliveira, Paolo (författare)
- University of Porto
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- Elneil, Sohier (författare)
- University College London Hospital
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- Hughes, John (författare)
- James Cook University Hospital
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- Messelink, Bert E.J. (författare)
- Medical Center Leeuwarden
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- Abreu-Mendes, Pedro (författare)
- University of Porto
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- Sacks, Benjamin (författare)
- University College London Hospital
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- Yuan, Yuhong (författare)
- McMaster University
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- Engeler, Daniel S. (författare)
- University of St. Gallen
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University of St Gallen Royal Devon & Exeter Hospital (creator_code:org_t)
- 2023
- 2023
- Engelska 10 s.
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Ingår i: European Urology Open Science. - 2666-1691. ; 56, s. 29-38
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Context: Radiotherapy of the pelvis is a widely used method for the treatment of malignancies, and local complications including pain following pelvic radiation therapy are acknowledged complications. Objective: The primary objective is to assess the clinical effectiveness and safety of pharmacological therapies on postradiation pelvic pain. Evidence acquisition: A systematic review of the use of different pharmacological treatments in the management of post-radiation pelvic pain was conducted (PROSPERO-ID: CRD42021249026). Comprehensive searches of EMBASE, Medline, and Cochrane library were performed for publications between January 1980 and April 2021. The primary outcomes were improvement in pain and adverse events following treatment. The secondary outcomes included quality of life, bowel function, and urinary function. Evidence synthesis: After screening 1514 abstracts, four randomised controlled trials were identified, enrolling 355 patients with bladder and anorectal subtypes of postradiotherapy chronic pelvic pain (CPP). A narrative synthesis was performed as heterogeneity of included studies precluded a meta-analysis. A single study reported a significant reduction in pain after 6 mo in patients with bladder pain syndrome treated with hyaluronic acid or hyperbaric oxygen. Anorectal pain was reported to be reduced by the application of 4% formalin, but the use of hyperbaric oxygen in postradiotherapy anorectal pain remains controversial. Adverse event reporting was generally poor. Studies looking at medications used routinely in guidelines for neuropathic pain, such as gabapentin, pregabalin, amitriptyline, and duloxetine, were absent or of poor quality when it came to postradiation pelvic pain. Conclusions: Beneficial effects of hyperbaric oxygen or formalin on pain, quality of life, and functional symptoms were seen in patients with certain CPP subtypes, but the current evidence level is too weak to allow recommendations about the use of any pharmacological treatment for postradiation pelvic pain. Patient summary: Different pharmacological treatments are used to treat pain after radiotherapy, but current studies are of insufficient quality to determine whether these should be recommended and many chronic pelvic pain subtypes are not covered. Further research is needed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Chronic painful radiation-induced neuropathy
- Chronic pelvic pain
- Chronic post cancer treatment pain
- Chronic post radiotherapy pain
- Pelvic radiation disease
- Postradiation
- Radiotherapy
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Zumstein, Valent ...
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Parsons, Brian A ...
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Dabestani, Saeed
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Baranowski, Andr ...
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Tidman, Victoria
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Berghmans, Bary
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visa fler...
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Borovicka, Jan
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Cottrell, Angela ...
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Dinis-Oliveira, ...
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Elneil, Sohier
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Hughes, John
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Messelink, Bert ...
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Abreu-Mendes, Pe ...
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Sacks, Benjamin
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Yuan, Yuhong
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Engeler, Daniel ...
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