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From Substance Use ...
From Substance Use Disorders in Life to Autopsy Findings : A Combined Case-Record and Medico-Legal Study
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- Brådvik, Louise (författare)
- Lund University,Lunds universitet,Lundbystudien,Forskargrupper vid Lunds universitet,The Lundby Study,Lund University Research Groups
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- Löwenhielm, Peter (författare)
- Lund University,Lunds universitet,Rättsmedicin,Forskargrupper vid Lunds universitet,Forensic Medicine,Lund University Research Groups
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- Frank, Arne (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Berglund, Mats (författare)
- Lund University,Lunds universitet,Enheten för klinisk beroendeforskning,Forskargrupper vid Lunds universitet,Clinical addiction research unit,Lund University Research Groups
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(creator_code:org_t)
- 2019-03-05
- 2019
- Engelska.
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1660-4601. ; 16:5
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Objectives: Several studies have shown mortality and suicide risk in substance use disorders, and autopsy findings with respect to the used substances. However, there seems to be a gap in the knowledge about substances misused in life and at death at the within-person level. Methods: All consecutive, autopsied patients during 1993 to 1997, who had been in contact with the Addiction Centre in Malmö from 1968, were investigated (365 subjects). Drug misuse in the long-term course noted in case records was related to autopsy findings. Self-inflicted death (suicide/undetermined suicide/accidental overdose) was compared with natural death. Results: Benzodiazepine misuse was associated with a high risk of autopsy findings of the substance in suicide and death of undetermined intent. It was also associated among non-misusers, but less so. An alcohol level above 1‰ was found more often in self-inflicted death. Prescription opioids at autopsy were mainly found in self-inflicted death among non-misusers. Heroin misuse was related to overdose. Central nervous system stimulants (CNS-S) and cannabis were rarely found in self-inflicted death among previous misusers. The overlap between depression in life and antidepressants at death was low. Conclusions: Benzodiazepines and alcohol seem to disinhibit suicidal tendencies. Suicide risk among users of cannabis and CNS-S may be related to other risk factors than acute use. Implications for suicide prevention are discussed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Beroendelära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Substance Abuse (hsv//eng)
Nyckelord
- autopsy findings
- case records
- depression
- substance use disorders
- suicide risk
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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