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Novel markers of no...
Novel markers of normal and neoplastic human plasmacytoid dendritic cells
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Marafioti, Teresa (författare)
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Paterson, Jennifer C (författare)
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Ballabio, Erica (författare)
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visa fler...
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Reichard, Kaaren K (författare)
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Tedoldi, Sara (författare)
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Hollowood, Kevin (författare)
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- Dictor, Michael (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Hansmann, Martin-Leo (författare)
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Pileri, Stefano A (författare)
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Dyer, Martin J (författare)
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Sozzani, Silvano (författare)
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Dikic, Ivan (författare)
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Shaw, Andrey S (författare)
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Petrella, Tony (författare)
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Stein, Harald (författare)
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Isaacson, Peter G (författare)
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Facchetti, Fabio (författare)
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Mason, David Y (författare)
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(creator_code:org_t)
- American Society of Hematology, 2008
- 2008
- Engelska.
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Ingår i: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 111:7, s. 3778-3792
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Plasmacytoid dendritic cells (pDCs) are involved in innate immunity (eg, by secreting interferons) and also give rise to CD4(+)CD56(+) hematodermic neoplasms. We report extensive characterization of human pDCs in routine tissue samples, documenting the expression of 19 immunohistologic markers, including signaling molecules (eg, BLNK), transcription factors (eg, ICSBP/IRF8 and PU.1), and Toll-like receptors (TLR7, TLR9). Many of these molecules are expressed in other cell types (principally B cells), but the adaptor protein CD2AP was essentially restricted to pDCs, and is therefore a novel immunohistologic marker for use in tissue biopsies. We found little evidence for activation-associated morphologic or phenotypic changes in conditions where pDCs are greatly increased (eg, Kikuchi disease). Most of the molecules were retained in the majority of pDC neoplasms, and 3 (BCL11A, CD2AP, and ICSBP/IRF8) were also commonly negative in leukemia cutis (acute myeloid leukemia in the skin), a tumor that may mimic pDC neoplasia. In summary, we have documented a range of molecules (notably those associated with B cells) expressed by pDCs in tissues and peripheral blood (where pDCs were detectable in cytospins at a frequency of < 1% of mononuclear cells) and also defined potential new markers (in particular CD2AP) for the diagnosis of pDC tumors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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Marafioti, Teres ...
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Paterson, Jennif ...
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Ballabio, Erica
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Reichard, Kaaren ...
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Tedoldi, Sara
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Hollowood, Kevin
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visa fler...
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Dictor, Michael
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Hansmann, Martin ...
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Pileri, Stefano ...
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Dyer, Martin J
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Sozzani, Silvano
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Dikic, Ivan
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Shaw, Andrey S
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Petrella, Tony
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Stein, Harald
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Isaacson, Peter ...
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Facchetti, Fabio
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Mason, David Y
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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Blood
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Lunds universitet