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Familial Aggregatio...
Familial Aggregation of Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia with Solid Tumors and Myeloid Malignancies
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- Kristinsson, Sigurdur Y. (författare)
- Karolinska Institutet
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Goldin, Lynn R. (författare)
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- Turesson, Ingemar (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Bjorkholm, Magnus (författare)
- Karolinska Institutet
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Landgren, Ola (författare)
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(creator_code:org_t)
- 2012-02-03
- 2012
- Engelska.
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Ingår i: Acta Haematologica. - : S. Karger AG. - 1421-9662 .- 0001-5792. ; 127:3, s. 173-177
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Abstract
Ämnesord
Stäng
- Lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) is a B-cell disorder resulting from the accumulation, predominantly in the bone marrow, of clonally related lymphoplasmacytic cells. LPL/WM is a very rare disease, with an incidence rate of 3-4 cases per million people per year. Currently, the causes of LPL/WM are poorly understood; however, there are emerging data to support a role for immune-related factors in the pathogenesis of LPL/WM. In addition, data show that genetic factors are of importance in the etiology of LPL/WM. In this paper, we will review the current knowledge about familiality of LPL/WM and provide novel data on solid tumors and myeloid malignancies in first-degree relatives of LPL/WM patients. Copyright (C) 2012 S. Karger AG, Basel
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Autoimmunity
- Familial aggregation
- Hematological malignancies
- Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia
- Monoclonal
- gammopathy of undetermined significance
- Solid tumors
- Susceptibility
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