Sökning: onr:"swepub:oai:lup.lub.lu.se:e580fbca-5578-4898-8356-af5df9c2201a" >
Multi-Infection Pat...
Multi-Infection Patterns and Co-infection Preference of 27 Human Papillomavirus Types Among 137,943 Gynecological Outpatients Across China
-
- Liao, Guangdong (författare)
- Sichuan University
-
- Jiang, Xiyi (författare)
- Hangzhou Medical College, Hangzhou
-
- She, Bin (författare)
- Tellgen Corporation
-
visa fler...
-
- Tang, Huijuan (författare)
- Hangzhou Medical College, Hangzhou
-
- Wang, Zhongyong (författare)
- The First Affiliated Hospital of Wenzhou Medical University, Wenzhou
-
- Zhou, Hongrong (författare)
- Changning Maternity and Infant Health Hospital, Shanghai
-
- Ma, Yan (författare)
- The First Affiliated Hospital of University of South China, Hengyang
-
- Xu, Weidong (författare)
- Suzhou Municipal Hospital, Suzhou
-
- Xu, Hongxing (författare)
- Suzhou Municipal Hospital, Suzhou
-
- Chen, Wen (författare)
- Peking Union Medical College
-
- Ji, Jianguang (författare)
- Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
-
- Xi, Mingrong (författare)
- Sichuan University
-
- Chen, Tianhui (författare)
- Zhejiang Cancer Hospital,Chinese Academy of Sciences
-
visa färre...
-
(creator_code:org_t)
- 2020-04-07
- 2020
- Engelska.
-
Ingår i: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 10
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://www.frontier...
-
https://lup.lub.lu.s...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: The epidemiological feature of human papillomavirus (HPV) infection is distinctive in China. We aimed to investigate the multi-infection patterns and co-infection preference of 27 HPV types among gynecological outpatients across China. Methods: Overall 137,943 gynecological outpatients were recruited from eight tertiary hospitals located in seven regions of China, between July 1st, 2014 and December 31st, 2016. The overall, region-specific, age-specific and type-specific prevalence of HPV infection were calculated, respectively. The pattern of HPV infection was also evaluated. Furthermore, rate ratio was calculated to evaluate the co-infection preference of any two HPV genotypes. Results: The overall prevalence of 27 HPVs' [17 high-risk (hr)/10 low-risk (lr)] infection was 23.5%. The age-specific HPV prevalence showed a "U-shaped" pattern. The most prevalent hrHPV genotypes were 16, 52, and 58. Multiple infections were detected in 25.8% of the HPV-positive women, in which dual infection was more prevalent. HPV 16/18 were likely to co-infected with HPV 31 but unlikely with HPV 52/58, i.e., the co-infection of HPV 16 with HPV 31 was high (3.5-fold), but low for HPV 58 (1.8-fold), and 52 (1.2-fold), while the co-infection of HPV 18 with HPV 31 was high (4.3-fold), but low for HPV 52 (1.9-fold), and 58 (1.7-fold). Conclusions: We found age-specific prevalence of HPV infection showed a "U-shaped" pattern for high and low risk HPV, suggesting the importance of screening among younger women and the necessary of detection among older women. We found a novel co-infection preference of HPV 16/18 with 31, 52, and 58, suggesting a need of developing and marketing prophylactic HPV vaccines that protect against more genotypes in China.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Liao, Guangdong
-
Jiang, Xiyi
-
She, Bin
-
Tang, Huijuan
-
Wang, Zhongyong
-
Zhou, Hongrong
-
visa fler...
-
Ma, Yan
-
Xu, Weidong
-
Xu, Hongxing
-
Chen, Wen
-
Ji, Jianguang
-
Xi, Mingrong
-
Chen, Tianhui
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Frontiers in Onc ...
- Av lärosätet
-
Lunds universitet