Sökning: onr:"swepub:oai:lup.lub.lu.se:e59b3955-c5e6-46a7-b39b-ad1936329a6f" > Neuropathological p...
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000 | 02969naa a2200409 4500 | |
001 | oai:lup.lub.lu.se:e59b3955-c5e6-46a7-b39b-ad1936329a6f | |
003 | SwePub | |
008 | 160401s2007 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:115700675 | |
024 | 7 | a https://lup.lub.lu.se/record/6929912 URI |
024 | 7 | a https://doi.org/10.1111/j.1600-0404.2007.00837.x2 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1157006752 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a H-Stenstam, B.4 aut |
245 | 1 0 | a Neuropathological postmortem evaluation of BNCT for GBM |
264 | 1 | b Hindawi Limited,c 2007 |
520 | a Background - Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. Objective - The present study was designed to assess tumor efficacy and radiation damage to the brain for the seven patients in the Studsvik trial that were available for postmortem neuropathological examination. Method - Whole brain slices containing the initial tumor site and other regions showing pathological changes were chosen for microscopy and selected areas were studied by immunological methods. Results - Local control of GBM was observed in all cases. Conclusive evidence for radiation induced brain damage was not found. Conclusion - Using a novel procedure for BPA infusion, BNCT achieves local control of GBM for minimum tumor doses as low as 15 wGy, allowing treatment with very low concomitant doses to surrounding healthy tissues. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a boron neutron capture therapy | |
653 | a glioblastoma multiforme | |
653 | a postmortem | |
653 | a evaluation | |
700 | 1 | a Pellettieri, L.4 aut |
700 | 1 | a Skold, K.4 aut |
700 | 1 | a Rezaei, A.4 aut |
700 | 1 | a Brun, Arneu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-ab8 |
710 | 2 | a Tumörmikromiljöb Sektion I4 org |
773 | 0 | t Acta Neurologica Scandinavicad : Hindawi Limitedg 116:3, s. 169-176q 116:3<169-176x 1600-0404x 0001-6314 |
856 | 4 | u http://dx.doi.org/10.1111/j.1600-0404.2007.00837.xy FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/692991 |
856 | 4 8 | u https://doi.org/10.1111/j.1600-0404.2007.00837.x |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:115700675 |
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