Sökning: onr:"swepub:oai:lup.lub.lu.se:e64e7174-505b-4200-883f-e04466b6b410" >
IgM anti-malondiald...
IgM anti-malondialdehyde low density lipoprotein antibody levels indicate coronary heart disease and necrotic core characteristics in the Nordic Diltiazem (NORDIL) study and the Integrated Imaging and Biomarker Study 3 (IBIS-3)
-
- van den Berg, Victor J (författare)
- Erasmus University Medical Center
-
- Haskard, Dorian O (författare)
- Imperial College London
-
- Fedorowski, Artur (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
-
visa fler...
-
- Hartley, Adam (författare)
- Imperial College London
-
- Kardys, Isabella (författare)
- Erasmus University Medical Center
-
Caga-Anan, Mikhail (författare)
-
Akkerhuis, K Martijn (författare)
-
Oemrawsingh, Rohit M (författare)
-
van Geuns, Robert Jan (författare)
-
de Jaegere, Peter (författare)
-
van Mieghem, Nicolas (författare)
-
Regar, Evelyn (författare)
-
Ligthart, Jurgen M R (författare)
-
- Umans, Victor A W M (författare)
- Northwest Hospital Group, Alkmaar
-
Serruys, Patrick W (författare)
-
- Melander, Olle (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups
-
Boersma, Eric (författare)
-
- Khamis, Ramzi Y (författare)
- Imperial College London
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
-
Ingår i: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 36, s. 63-72
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
http://www.thelancet...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Certain immunoglobulins (Ig) are proposed to have protective functions in atherosclerosis.Objectives: We tested whether serum levels of IgG and IgM autoantibodies against malondialdehyde low density lipoprotein (MDA-LDL) are associated with clinical coronary heart disease (CHD) and unfavorable plaque characteristics.Methods: NORDIL was a prospective study investigating adverse cardiovascular outcomes in hypertensive patients. IBIS-3 analyzed lesions in a non-culprit coronary artery with <50% stenosis using radiofrequency intravascular ultrasound (RF-IVUS) and near-infrared spectroscopy (NIRS). Imaging was repeated after a median of 386?days on rosuvastatin. Associations of antibodies with incident CHD and imaging parameters were assessed in the two sub-studies respectively.Findings: From 10,881 NORDIL patients, 87 had serum sampled at baseline and developed CHD over 4.5 years, matched to 227 controls. Higher titers of IgM anti-MDA-LDL had a protective effect on adverse outcomes, with odds ratio 0.29 (0.11, 0.76; p=0.012; p=0.016 for trend). Therefore, the effect was explored at the lesional level in IBIS-3. 143 patients had blood samples and RF-IVUS measurements available, and NIRS was performed in 90 of these. At baseline, IgM anti-MDA-LDL levels had a strong independent inverse relationship with lesional necrotic core volume (p=0.027) and percentage of plaque occupied by necrotic core (p=0.011), as well as lipid core burden index (p=0.024) in the worst 4 mm segment.Interpretation: Our study supports the hypothesis that lower circulating levels of IgM anti-MDA-LDL are associated with clinical CHD development, and for the first time relates these findings to atherosclerotic plaque characteristics that are linked to vulnerability.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Aged
- Atherosclerosis/blood
- Biomarkers/blood
- Coronary Artery Disease/blood
- Female
- Humans
- Immunoglobulin M/blood
- Lipoproteins, LDL/immunology
- Male
- Malondialdehyde/analogs & derivatives
- Middle Aged
- Necrosis/blood
- Prospective Studies
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
van den Berg, Vi ...
-
Haskard, Dorian ...
-
Fedorowski, Artu ...
-
Hartley, Adam
-
Kardys, Isabella
-
Caga-Anan, Mikha ...
-
visa fler...
-
Akkerhuis, K Mar ...
-
Oemrawsingh, Roh ...
-
van Geuns, Rober ...
-
de Jaegere, Pete ...
-
van Mieghem, Nic ...
-
Regar, Evelyn
-
Ligthart, Jurgen ...
-
Umans, Victor A ...
-
Serruys, Patrick ...
-
Melander, Olle
-
Boersma, Eric
-
Khamis, Ramzi Y
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
EBioMedicine
- Av lärosätet
-
Lunds universitet