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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03493naa a2200445 4500 | |
| 001 | oai:lup.lub.lu.se:e80678e3-84ad-443d-a982-2270e7a49c50 | |
| 003 | SwePub | |
| 008 | 211113s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/e80678e3-84ad-443d-a982-2270e7a49c502 URI |
| 024 | 7 | a https://doi.org/10.3390/v131121712 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Happonen, Lotta J.u Lund University,Lunds universitet,Molekylär patogenes,Forskargrupper vid Lunds universitet,BioMS,Molecular Pathogenesis,Lund University Research Groups4 aut0 (Swepub:lu)immu-loh |
| 245 | 1 0 | a BtuB-dependent infection of the T5-like Yersinia phage φr2-01 |
| 264 | c 2021-10-28 | |
| 264 | 1 | b MDPI AG,c 2021 |
| 520 | a Yersinia enterocolitica is a food-borne Gram-negative pathogen responsible for several gastrointestinal disorders. Host-specific lytic bacteriophages have been increasingly used recently as an alternative or complementary treatment to combat bacterial infections, especially when antibiotics fail. Here, we describe the proteogenomic characterization and host receptor identification of the siphovirus vB_YenS_φR2-01 (in short, φR2-01) that infects strains of several Yersinia enterocolitica serotypes. The φR2-01 genome contains 154 predicted genes, 117 of which encode products that are homologous to those of Escherichia bacteriophage T5. The φR2-01 and T5 genomes are largely syntenic, with the major differences residing in areas encoding hypothetical φR2-01 proteins. Label-free massspectrometry-based proteomics confirmed the expression of 90 of the φR2-01 genes, with 88 of these being either phage particle structural or phage-particle-associated proteins. In vitro transposon-based host mutagenesis and φR2-01 adsorption experiments identified the outer membrane vitamin B12 receptor BtuB as the host receptor. This study provides a proteogenomic characterization of a T5-type bacteriophage and identifies specific Y. enterocolitica strains sensitive to infection with possible future applications of φR2-01 as a food biocontrol or phage therapy agent. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng |
| 653 | a Bacteriophage | |
| 653 | a BtuB | |
| 653 | a Escherichia phage T5 | |
| 653 | a Genome | |
| 653 | a Phage φR2-01 | |
| 653 | a Proteome | |
| 653 | a Yersinia enterocolitica | |
| 700 | 1 | a Pajunen, Maria I.u University of Helsinki4 aut |
| 700 | 1 | a Jun, Jin Woou The Korea National College of Agriculture and Fisheries4 aut |
| 700 | 1 | a Skurnik, Mikaelu University of Helsinki4 aut |
| 710 | 2 | a Molekylär patogenesb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Virusesd : MDPI AGg 13:11, s. 1-18q 13:11<1-18x 1999-4915 |
| 856 | 4 | u http://dx.doi.org/10.3390/v13112171x freey FULLTEXT |
| 856 | 4 | u https://www.mdpi.com/1999-4915/13/11/2171/pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/e80678e3-84ad-443d-a982-2270e7a49c50 |
| 856 | 4 8 | u https://doi.org/10.3390/v13112171 |
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